| thrombotic phlegmasia | An extreme edematous swelling of the leg following childbirth, due to thrombosis of the iliofemoral veins. Synonym: leukophlegmasia dolens, milk leg, puerperal phlebitis, thrombotic phlegmasia, white leg. (05 Mar 2000) |
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| thrombotic thrombocytopenic purpura | A rapidly fatal or occasionally protracted disease with varied symptoms in addition to purpura, including signs of central nervous system involvement, due to formation of fibrin or platelet thrombi in arterioles and capillaries in many organs. Synonym: Moschcowitz' disease. (05 Mar 2000) |
| thrombotonin | 5-hydroxytryptamine |
| thromboxane | <biochemistry> Arachidonic acid metabolites produced by the action of thromboxane synthetase on prostaglandin cyclic endoperoxides. Thromboxane A2 (TxA2) is a potent inducer of platelet aggregation and release and although unstable, the activation of platelets leads to the further production of TxA2. Also causes arteriolar constriction. Another endoperoxide product, prostacyclin, has the opposite effects. (18 Nov 1997) |
| thromboxane a2 | <chemical> An unstable intermediate between the prostaglandin endoperoxides and thromboxane b2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (rcs). Chemical name: Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9alpha,11alpha,13E,15S)- (12 Dec 1998) |
| thromboxane b2 | <chemical> A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin). Chemical name: Thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,13E,15S)- (12 Dec 1998) |
| thromboxane dehydrogenase | <enzyme> Converts thromboxane b2 to 11-dehydro-thromboxane b2, but not the reverse reaction; uses nad but not nadp as cofactor; only attacks the 11-hydroxy group of txb2 Registry number: EC 1.1.1.- Synonym: thromboxane b2 dehydrogenase, 11-hydroxythromboxane b2 dehydrogenase, 11-hydroxy-txb2 dehydrogenase (26 Jun 1999) |
| thromboxane-a synthase | <enzyme> An enzyme found predominantly in platelet microsomes. It catalyses the conversion of pgg(2) and pgh(2) (prostaglandin endoperoxides) to thromboxane a2. Chemical name: (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A(2)-isomerase Registry number: EC 5.3.99.5 (12 Dec 1998) |
| thromboxanes | Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase. (12 Dec 1998) |
| thrombozyme | <haematology> Traditional name for substance in plasma that converts prothrombin to thrombin. Now known not to be a single substance. (See thrombin). (18 Nov 1997) |
| thrombus | <haematology> An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation. Some authorities thus differentiate thrombus formation from simple coagulation or clot formation. Compare: embolism. Origin: Gr. Thrombos = clot (18 Nov 1997) |
| throstle | 1. <zoology> The song thrush. See Song. 2. A machine for spinning wool, cotton, etc, from the rove, consisting of a set of drawing rollers with bobbins and flyers, and differing from the mule in having the twisting apparatus stationary and the processes continuous; so called because it makes a singing noise. Throstle cock, the missel thrush. Origin: OE. Throsel, AS. Rostle, rosle; akin to MHG. Trostel, G. Drossel, Icel. Rostr, Sw. Trast, Lith. Strazdas, L. Turdus. 238. Cf. Thrush the bird. Source: Websters Dictionary (01 Mar 1998) |
| throstling | A disease of bovine cattle, consisting of a swelling under the throat, which, unless checked, causes strangulation. Origin: Cf. Throttle. Source: Websters Dictionary (01 Mar 1998) |
| throttle | 1. To have the throat obstructed so as to be in danger of suffocation; to choke; to suffocate. 2. To breathe hard, as when nearly suffocated. Source: Websters Dictionary (01 Mar 1998) |
| throttler | 1. One who, or that which, throttles, or chokes. 2. <zoology> See Flasher, 3 . Source: Websters Dictionary (01 Mar 1998) |