| oestriol | <chemical> (16 alpha,17 beta)-estra-1,3,5(10)-triene-3,16,17-triol. A metabolite of estradiol and usually the predominant oestrogenic metabolite in urine. During pregnancy, large amounts of estriol are produced by the placenta. It has also been obtained from plant sources. The 16 beta-isomer has also been isolated from the urine of pregnant women. Chemical name: Estra-1,3,5(10)-triene-3,16,17-triol, (16alpha,17beta)- (12 Dec 1998) |
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| oestrogen | <endocrinology, hormone> A generic term for oestrus producing steroid compounds, the female sex hormones. In humans, oestrogen is formed in the ovary, possibly the adrenal cortex, the testis and the foetoplacental unit, it has various functions in both sexes. It is responsible for the development of the female secondary sex characteristics and during the menstrual cycle it acts on the female genitalia to produce an environment suitable for the fertilization, implantation and nutrition of the early embryo. Oestrogen is used in oral contraceptives and as a palliative in cancer of the breast after menopause and cancer of the prostate, other uses include the relief of the discomforts of menopause, inhibition of lactation and treatment of osteoporosis, threatened abortion and various functional ovarian disorders. (18 Nov 1997) |
| oestrogen antagonist | <pharmacology> A drug or compound which inhibit or antagonise the action or biosynthesis of oestrogen. Tamoxifen also has agonist or stimulatory actions as well as blocking effects. There are also selective oestrogen-receptor modulators (SERMs). For example, raloxifene (trade name Evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus. (12 May 2002) |
| oestrogen receptor | <cell biology> Cytoplasmic proteins that bind oestrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of oestrogen receptors in breast cancer patients has become clinically important and determines the likelihood of response to anti-oestrogen therapy with tamoxifen. (17 Jul 2002) |
| oestrogen replacement therapy | <endocrinology, gynaecology> The use of oestrogenic substances in postmenopausal or other oestrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, dyspareunia, and progressive development of osteoporosis. (12 Dec 1998) |
| oestrogenic | 1. Causing estrus in animals. 2. Having an action similar to that of an oestrogen. (05 Mar 2000) |
| oestrogenic hormone | <pharmacology> A female hormone produced by the ovaries (or an equivalent hormone synthesised in the laboratory). Oestrogen deficiency can lead to osteoporosis. (12 Dec 1998) |
| oestrogenism | <veterinary> A mycotoxic disease of pigs associated with eating moldy feeds containing the fungus Fusarium graminearum; the causative toxin is zeralenone, which produces a form of vulvovaginitis. (05 Mar 2000) |
| oestrogens | A class of sex hormones associated with the development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle. They are also required for pregnancy maintenance and have an anabolic effect on protein metabolism and water retention. (12 Dec 1998) |
| oestrogens, catechol | 2- or 4-hydroxyoestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an oestrogenic action or interaction with the catecholaminergic system. (12 Dec 1998) |
| oestrogens, conjugated | An amorphous preparation containing water-soluble, conjugated forms of mixed oestrogens obtained from urine of pregnant mares. The principal oestrogen present is sodium estrone sulfate. The total oestrogenic potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate. (12 Dec 1998) |
| oestrogens, synthetic | Compounds obtained by chemical synthesis which possess oestrogenic activity, but differ in structure from naturally occurring oestrogens. (12 Dec 1998) |
| oestrone | <chemical> 3-hydroxyestra-1,3,5(10)-trien-17-one. A metabolite of estradiol but possessing less biological activity. It is found in the urine of pregnant women and mares, in the human placenta, and in the urine of bulls and stallions. According to the fourth annual report on carcinogens (ntp 85-002, 1985), estrone may reasonably be anticipated to be a carcinogen (merck, 11th ed). Chemical name: Estra-1,3,5(10)-trien-17-one, 3-hydroxy- (12 Dec 1998) |
| oestrosis | Infection of small ruminants and rarely humans with larvae of the fly Oestrus ovis. (05 Mar 2000) |
| oestrual | <physiology> Of or pertaining to sexual desire; mostly applied to brute animals; as, the oestrual period; oestrual influence. See: oestrus. Source: Websters Dictionary (01 Mar 1998) |
| Oehler's symptom |
see under symptom.
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| oesophag(o)- |
for words beginning thus, see those beginning esophag(o)-.
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| Oesophagodontus |
a genus of nematodes of the family Strongylidae. O. robus´tus is a blood-sucking parasite in the colon of the horse.
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| oesophagostomiasis |
infection with nematodes of the genus Oesophagostomum. See nodular worm disease, under disease.
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| oestr- |
for words beginning thus, see also those beginning estr-.
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