| neoplasms, multiple primary | Two or more abnormal growths of tissue occurring simultaneously. The neoplasms are histologically different and may be found in the same or different sites. (12 Dec 1998) |
|---|---|
| drug resistance, multiple | Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. (12 Dec 1998) |
| exostoses, multiple hereditary | Hereditary disorder transmitted by an autosomal dominant gene and characterised by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation. (12 Dec 1998) |
| familial multiple endocrine adenomatosis | The presence of functioning tumours in more than one endocrine gland, commonly the pancreatic islets and parathyroid glands, which may be associated with Zollinger-Ellison syndrome; dominant inheritance. Synonym: multiple endocrine adenomatosis. (05 Mar 2000) |
| law of multiple proportions | The relative weights in which two substances form a chemical union singly with a third are the same as, or simple multiples of, those in which they unite with each other; a corollary of the law of definite proportions. Synonym: law of multiple proportions. (05 Mar 2000) |
| lipomatosis, multiple symmetrical | Multiple circumscribed or encapsulated lipomas which may be distributed symmetrically or haphazardly or which may form a collar around the neck. (12 Dec 1998) |
| acetyl CoA-(beta-aminoethyl)-L-cysteine omega-N-acetyltransferase | <enzyme> Forms s-(beta-n-acetyl-aminoethyl)-l-cysteine Registry number: EC 2.3.1.- Synonym: acoac-acetyltransferase, acetyl coenzyme a-(beta-aminoethyl)-l-cysteine omega-n-acetyltransferase (26 Jun 1999) |
| acetylgalactosaminylgalactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase | <enzyme> Forms galnac-beta1-3galnac-beta1-3gal-alpha1-4gal-beta1-4glc-cer Registry number: EC 2.4.1.- Synonym: forssman glycolipid synthase, udp-galnac globotetraoside n-acetylgalactosaminyl transferase (26 Jun 1999) |
| acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase | <enzyme> Forms oligosaccharide core class 3 (glcnac beta 1-3galnac) in mucins and various glycoproteins Registry number: EC 2.4.1.147 Synonym: udp-glcnac-galnac-r beta 3-acetylglucosaminyltransferase, agggag-transferase (26 Jun 1999) |
| acyl-CoA-estradiol-17-beta-acyltransferase | <enzyme> Catalyses the esterification of estradiol with long chain fatty acids at the 17-position Registry number: EC 2.3.1.- Synonym: acylcoenzyme a-estradiol-17-beta-acyltransferase, estradiol 17-acyltransferase (26 Jun 1999) |
| adrenergic beta-agonists | Drugs that selectively bind to and activate beta-adrenergic receptors. (12 Dec 1998) |
| adrenergic beta-antagonists | Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (12 Dec 1998) |
| alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase | <enzyme> Incorporates n-acetyglucosamine as the third branch of complex n-glycosyl-oligosaccharide of hen oviduct Registry number: EC 2.4.1.145 Synonym: glcnac-transferase iv, n-acetylglucosaminyltransferase iv, udp-glcnac-gngn(glcnac to man alpha1-3)beta 4-n-acetylglucosaminyltransferase iv (26 Jun 1999) |
| alpha-amino-beta-ketoadipic acid | 2-Amino-3-oxo-1,6-hexanedioic acid;an intermediate of porphobilinogen synthesis formed by d-aminolevulinic acid synthase from succinyl-CoA and glycine; it rapidly decarboxylates to d-aminolevulinic acid. (05 Mar 2000) |
| alpha,beta-ketoalkene reductase | <enzyme> Nadh is much less effective than NADPH; catalyses the reduction of the carbon-carbon double bond of five membered ring cpds which have two conjugated carbonyl groups on both sides of a double bond Registry number: EC 1.3.1.- Synonym: n-ethylmaleimide reducing enzyme, NADPH-linked alpha,beta-ketoalkene double bond reductase, n-ethylmaleimide reductase (26 Jun 1999) |