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insulin r.’s specific membrane receptors for insulin found on target cells. When insulin binds to a receptor, either the receptor protein kinase is activated, leading to the activation of other protein kinases within the cell, or the occupied receptors move to coated pits and are endocytosed; in the latter case, in addition to the effects mediated by kinases, a few effects may depend on degradation products.
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insulin s. a hypoglycemic reaction to overdosage of insulin, a skipped meal, or strenuous exercise in an insulin-dependent diabetic; early symptoms are tremor, irritability, dizziness, cool moist skin, hunger, and tachycardia; if untreated it can progress to coma (see diabetic coma) and convulsions. Called also hypoglycemic s.
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insulin-dependent d. mellitus type 1 d. mellitus.
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insulin-induced h. factitial h.
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insulinlike growth f.’s serum peptides with insulin-like actions, formerly called somatomedins (q.v.). IGF-I (formerly somatomedin C) is an important growth hormone–dependent mediator of cell growth and replication. IGF-II (formerly somatomedin A) appears to be essential for normal embryonic development and may play special roles in the central nervous system. Both are similar in sequence and structure to proinsulin.
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