| GM-CSF | granulocyte-macrophage colony-stimulating factor |
|---|---|
| GPE | guinea pig embryo; granulocyte colony-stimulating factor promoter element |
| GPEBP | granulocyte colony-stimulating factor promoter element binding protein |
| GSFR | granulocyte colony-stimulating factor receptor |
| LSF | linear spread function; lymphocyte-stimulating factor |
| platelet-derived growth factor | <growth factor> The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing. It is carried in the alpha-granules of platelets and is released when platelets adhere to traumatised tissues. Connective tissue cells near the traumatised region respond by initiating the process of replication. The B chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for platelet derived growth factor, suggesting that transformation is caused by autocrine stimulation. The receptor is a tyrosine kinase. Acronym: PDGF (12 Dec 1998) |
|---|---|
| platelet factor 3 | <haematology> Phospholipid associated with the platelet plasma membrane that contributes to the blood clotting cascade by forming a complex (thromboplastin) with other plasma proteins and activating prothrombin. (31 Dec 1997) |
| platelet factor 4 | <haematology> Platelet released protein that promotes blood clotting by neutralising heparin. (31 Dec 1997) |
| platelet tissue factor | <haematology> Traditional name for substance in plasma that converts prothrombin to thrombin. Now known not to be a single substance. (See thrombin). (18 Nov 1997) |
| mullerian inhibiting factor | A 535 amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin. Synonym: mullerian inhibiting factor. (05 Mar 2000) |
| mullerian regression factor | Mullerian duct inhibitory factor, a non-steroidal substance of foetal testicular origin that acts unilaterally to inhibit development of the paramesonephric (mullerian) ducts and acts with testosterone to promote development of the vas deferens and related structures. (05 Mar 2000) |
| confounding factor | <epidemiology> Factors that can cause or prevent the outcome of interest, are not intermediate variables, and are not associated with the factor(s) under investigation. They give rise to situations in which the effects of two processes are not separated, or the contribution of causal factors cannot be separated, or the measure of the effect of exposure or risk is distorted because of its association with other factors influencing the outcome of the study. (03 Jul 1999) |
| cord factor | Glycolipid (trehalose 6, 6' dimycolate) found in the cell walls of Mycobacteria (causing them to grow in serpentine cords) and important in virulence, being toxic and inducing granulomatous reactions identical to those induced by the whole organism. (18 Nov 1997) |
| corticotrophin releasing factor | adrenocorticotrophin |
| corticotropin-releasing factor | <endocrinology, physiology> A neuropeptide released by the hypothalamus that stimulates the release of corticotropin by the anterior pituitary gland. Chemical name: Corticotropin-releasing factor Synonym: corticoliberin, corticotropin releasing factor. (12 Dec 1998) |
| myocardial depressant factor | A low molecular weight peptide of about 800-1000 having a negative inotropic effect. It is released into the circulation during experimental haemorrhagic pancreatitis, severe ischemia, and postoligaemic shock. (12 Dec 1998) |
| coupling factor | Protein responsible for coupling transmembrane potentials to ATP synthesis in chloroplasts and mitochondria. Include ATP synthesising enzymes (F1 in mitochondrion), that can also act as ATP ases. (18 Nov 1997) |
| Hageman factor | <chemical> Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor xii to xiia. Deficiency of factor xii, also called the hageman trait, leads to increased incidence of thromboembolic disease. Chemical name: Blood-coagulation factor XII (12 Dec 1998) |
| Hageman factor assay | A test used to measure the activity of a blood clotting factor XII. This test may be used to evaluate excessive bleeding. Low factor XII may be seen in cases of congenital deficiency of factor XII, heparin administration and liver disease. (27 Sep 1997) |
| hageman factor deficiency | A deficiency of a specific blood clotting factor (XII) that may be genetic or acquired. Administration of heparin or severe liver disease may result in factor XII (Hageman factor) deficiency. There are usually no symptoms associated with this deficiency, but there may be symptoms of mild blood loss in some cases. Treatment is generally unnecessary. Individuals should be cautioned against the use of medications (for example aspirin, warfarin, heparin) with anticoagulant activity, due to risk of exaggerated effects. (27 Sep 1997) |