| folic acid deficiency | A nutritional condition produced by a deficiency of folic acid in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anaemia, macrocytic anaemia, and megaloblastic anaemia. It is indistinguishable from vitamin b 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in b 12 deficiency do not occur. (merck manual, 16th ed) (12 Dec 1998) |
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| folic acid deficiency anaemia | Anaemia due to deficiency of folic acid, characterised by large-sized red blood cells (macrocytosis) and presence of large nuclei in erythroid precursor cells (megaloblasts) in the bone marrow. (05 Mar 2000) |
| LCAT deficiency | A rare condition characterised by corneal opacities, haemolytic anaemia, proteinuria, renal insufficiency, and premature atherosclerosis, and very low levels of lecithin cholesterol acyltransferase (LCAT) activity; results in accumulation of unesterfied cholesterol in plasma and tissues. (05 Mar 2000) |
| lecithin acyltransferase deficiency | A disease characterised by deficiency or low levels of plasma lecithin cholesterol acyl transferase. Clinical manifestations include corneal opacity, anaemia, and proteinuria. (12 Dec 1998) |
| fructose-1,6-diphosphatase deficiency | An autosomal recessive fructose metabolism disorder due to absent or deficient fructose-1,6-diphosphatase activity. Gluconeogenesis is impaired, resulting in accumulation of gluconeogenic precursors (e.g., amino acids, lactate, ketones) and manifested as hypoglycaemia, ketosis, and lactic acidosis. Episodes in the newborn infant are often lethal. Later episodes are often brought on by fasting and febrile infections. As patients age through early childhood, tolerance to fasting improves and development becomes normal. (12 Dec 1998) |
| leukocyte adhesion deficiency | An inherited disorder (autosomal recessive) in which there is a defective CD18 adherence complex that disturbs leukocyte chemotaxis. It is characterised by recurrent bacterial infections and impaired wound healing. (05 Mar 2000) |
| leukocyte-adhesion deficiency syndrome | <syndrome> Rare, autosomal recessive disorder caused by deficiency of the beta 2 integrin receptors (receptors, leukocyte-adhesion) comprising the CD11/CD18 family of glycoproteins. The syndrome is characterised by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection. (12 Dec 1998) |
| lipoprotein lipase deficiency, familial | A rare familial condition characterised by massive chylomicronaemia and decreased levels of other lipoproteins. It is due to deficiency of lipoprotein lipase, an alkaline triglyceride hydrolase which catalyses an important step in the extrahepatic removal of triglyceride-rich lipoproteins from the blood. (12 Dec 1998) |
| luteal phase deficiency | Inadequate function of the corpus luteum that may prevent a fertilized egg from implanting in the uterus or may lead to early pregnancy loss. (09 Oct 1997) |
| acute primary haemorrhagic meningoencephalitis | A disease characterised by acute onset of fever, followed by convulsions, delirium, and coma, and associated with perivascular demyelination and haemorrhagic foci in the central nervous system. Synonym: acute primary haemorrhagic meningoencephalitis, Strumpell's disease. (05 Mar 2000) |
| acyclic monoterpene primary alcohol - NADP oxidoreductase | <enzyme> From catmint nepeta racemosa; involved in the biosynthesis of iridoid monoterpenes; oxidises geraniol, nerol, and their 10-hydroxy derivatives in the presence of nadp(+). Registry number: EC 1.1.1.- Synonym: monoterpene primary alcohol - nadp oxidoreductase, ampano (26 Jun 1999) |
| anterior primary division | <anatomy, nerve> The larger, anterolaterally-directed major terminal branch (with the dorsal primary ramus) of all 31 pairs of mixed spinal nerves, formed at the intervertebral foramen. Most ventral primary rami, especially those involved in the innervation of the limbs, participate in the formation of the major nerve plexuses (cervical, brachial, and lumbosacral) and lose their identities. Most in the thoracic region, however, remain separate from adjacent rami to become the intercostal and subcostal nerves. Ventral primary rami provide innervation to the anterolateral body wall and trunk. Nomina Anatomica lists ventral primary rami as "rami ventrales" for each group of spinal nerves: 1) cervical (nervorum cervicalium ), 2) thoracic (nervorum thoracicorum ), 3) lumbar (nervorum lumbalium ), 4) sacral (nervorum sacralium )m, and 5) coccygeal (nervi coccygei ). Synonym: ramus ventralis nervi spinalis, anterior primary division. (05 Mar 2000) |
| aphasia, primary progressive | A type of aphasia appearing gradually and gradually worsening without any major change in other cognitive functions. It is regarded by some authors as a syndrome which may be due to various degenerative diseases of the cerebral cortex (notably alzheimer disease, owing to its frequency), while others see in it an autonomous disease related to a neuropathological process that is distinct from the main degenerative dementias. The principal clinical peculiarity of primary progressive aphasia is that it spares the patient's autonomy for a long time, but ultimately turns into global dementia. (12 Dec 1998) |
| ventral primary rami of cervical spinal nerves | See: ventral primary ramus of spinal nerve. Synonym: rami ventrales nervorum cervicalium. (05 Mar 2000) |
| ventral primary rami of lumbar spinal nerves | See: ventral primary ramus of spinal nerve. Synonym: rami ventrales nervorum lumbalium. (05 Mar 2000) |