| fibroblast growth factor, acidic | <chemical> A growth factor which has been isolated from a variety of cells. It contains 154 amino acid residues and has potent heparin-binding activity. Heparin potentiates the biological activities of afgf. The growth factor is an extremely potent inducer of DNA synthesis in a variety of normal diploid mammalian cell types from mesoderm and neuroectoderm lineages and also has chemotactic and mitogenic activities. Chemical name: Fibroblast growth factor (human brain acidic protein moiety reduced) (12 Dec 1998) |
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| fibroblast growth factor, basic | A single-chain polypeptide of approximately 15-16 kD which has been isolated from a variety of cells. It has a 55% amino acid residue identity to acidic fibroblast growth factor and has potent heparin-binding activity. However, in contrast to the acidic fibroblast growth factor, heparin does not potentiate the biological activities of bfgf. The growth factor is an extremely potent inducer of DNA synthesis in a variety of normal diploid mammalian cell types from mesoderm and neuroectoderm lineages and promotes cellular differentiation in vitro. (12 Dec 1998) |
| fibroblast growth factor receptor | Family of receptor tyrosine kinases for fibroblast growth factor. (18 Nov 1997) |
| fibroblast growth factor receptor-like embryonic kinase | <enzyme> Found in avian embryonic tissue; involved in early differentiation of skeletal muscle. Registry number: EC 2.7.1.- Synonym: frek (26 Jun 1999) |
| foetal growth retardation | The failure of a foetus to maintain its expected growth potential at any gestational stage. (12 Dec 1998) |
| adipokinetic hormone | An anterior pituitary hormone that causes mobilization of fat from adipose tissue. Synonym: adipokinetic hormone. (05 Mar 2000) |
| adrenal androgen-stimulating hormone | A putative pituitary hormone that may be responsible for increased secretion of adrenal androgens at the time of puberty. (05 Mar 2000) |
| adrenocorticotrophic hormone | <endocrinology> A peptide hormone that is produced by the anterior pituitary gland. It stimulates the adrenal cortex to secrete glucocorticoid hormones, which help cells synthesise glucose, catabolize proteins, mobilizefree fatty acids and inhibit inflammation in allergic responses. (10 May 1997) |
| adrenocorticotropic hormone | The hormone of the anterior lobe of the hypophysis which governs the nutrition and growth of the adrenal cortex, stimulates it to functional activity, and also possesses extraadrenal adipokinetic activity; it is a polypeptide containing 39 amino acids, but exact structure varies from one species to another; sometimes prefixed by a to distinguish it from beta-corticotropin. The first thirteen amino acids at the N-terminal region are identical to alpha-melanotropin. Synonym: adrenocorticotropin, adrenotropic hormone, adrenotropin, corticotropic hormone, corticotropin. (05 Mar 2000) |
| adrenotropic hormone | The hormone of the anterior lobe of the hypophysis which governs the nutrition and growth of the adrenal cortex, stimulates it to functional activity, and also possesses extraadrenal adipokinetic activity; it is a polypeptide containing 39 amino acids, but exact structure varies from one species to another; sometimes prefixed by a to distinguish it from beta-corticotropin. The first thirteen amino acids at the N-terminal region are identical to alpha-melanotropin. Synonym: adrenocorticotropin, adrenotropic hormone, adrenotropin, corticotropic hormone, corticotropin. (05 Mar 2000) |
| androgenic hormone | <endocrinology> A male (masculinising) hormone. These medications (testosterone, methyltestosterone, fluoxymesterone, danazol) are used to treat androgen deficiency, delayed puberty in males and some forms of breast cancer. (27 Sep 1997) |
| anterior pituitary-like hormone | A glycoprotein with a carbohydrate fraction composed of d-galactose and hexosamine, extracted from the urine of pregnant women and produced by the placental trophoblastic cells; its most important role appears to be stimulation, during the first trimester, of ovarian secretion of the oestrogen and progesterone required for the integrity of conceptus; it appears to play no significant role in the last two trimesters of pregnancy, as the oestrogen and progesterone are then formed by the placenta. Synonym: anterior pituitary-like hormone, choriogonadotropin, chorionic gonadotropic hormone, chorionic gonadotrophic hormone, placenta gonadotropin, placentagonadotropin. (05 Mar 2000) |
| antidiuretic hormone | <endocrinology> A peptide hormone released from the posterior pituitary lobe but synthesised in the hypothalamus. There are 2 forms, differing only in the amino acid at position 8: arginine vasopressin is widespread, while lysine vasopressin is found in pigs. Has antidiuretic and vasopressor actions. Used in the treatment of diabetes insipidus. Acronym: ADH (13 Nov 1997) |
| cardiac hormone | A substance present in extracts of cardiac tissue that augments cardiac contraction; possibly adenosine, a catecholamine, or some non-specific stimulant present generally in tissues. Synonym: cardiac hormone, heart hormone. (05 Mar 2000) |
| galactopoietic hormone | <protein> Pituitary lactogenic hormone (23 kD) Synthesised on endoplasmic reticulum bound ribosomes as preprolactin that has an N terminal signal peptide that is cleaved from the mature form. The conversion of preprolactin to prolactin has been much used as an assay for membrane insertion. (18 Nov 1997) |