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down-regulation a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. See also up-regulation.
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downbeat n. a vertical nystagmus with the fast phase downward, occurring in lesions at the cervicomedullary junction.
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downer cow s. parturient paresis in a cow that is intractable to treatment and usually fatal.
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Downey c.’s atypical lymphocytes of three types invariably present in infectious mononucleosis. Type I is a mature cell with a kidney-shaped or lobulated nucleus with vacuolated, basophilic foamy cytoplasm; type II cells contain plasmacytoid nuclei with less vacuolated and basophilic cytoplasm; type III has a finer chromatin pattern and one or two nucleoli.
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downgrading r. a lepra reaction, similar in appearance to the reversal (“upgrading”) reaction, representing a deterioration in the immune response to Mycobacterium leprae with worsening of the clinical symptoms of leprosy and an increased index of M. leprae in the tissues; it may be seen during antileprosy treatment in those in whom M. leprae has become drug resistant or in those with poor compliance with the chemotherapeutic regimen.
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