| wobble | In molecular biology, unorthodox pairing between the base at the 5' end of an anticodon and the base that pairs with it (in the 3'-position of the codon); thus, the anticodon 3'-UCU-5' may pair with 5'-AGA-3' (normal or Watson-Crick pairing) or with 5'-AGG-3' (wobble). Wobble pairings can occur between the unusual base hypoxanthine and adenine, uracil, or cytosine, between uracil and guanine, and between guanine and uracil, when in the 5'-position of an anticodon. See: wobble base. (05 Mar 2000) |
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| wobble base | The 3' codon base that is less strictly specified in the genetic code. See: wobble, wobble hypothesis. (05 Mar 2000) |
| wobble hypothesis | <molecular biology> Explains why the base Inosine is included in position 1 in the anticodons of various t RNAs, why many mRNA codon words translate to a single amino acid, why there are appreciably fewer t RNAs than mRNA codon types and why the redundant nature of the genetic code translates into a precise set of 20 amino acids. Inosine in Position 1 in the anticodon can base pair with A, u or C in position 3 in the mRNA codon, so that for example UCU, UCC, UCA all code for Serine using an inosine anticodon. (18 Nov 1997) |