| whole blood coagulation time | Measurement of the time required by whole blood to produce a visible clot. Factors that could influence the test are all but III, vii, and xiii. Activation may be by contact with the glass tube or exposure to diatomaceous earth. Delay of onset of coagulation may be achieved by use of nonwettable plastic or silicone-coated glass tubes. It is used for monitoring heparin therapy and as a bedside screening test for deficiencies in the intrinsic coagulation pathway. "activated coagulation time" is sometimes referred to as act. (12 Dec 1998) |
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| coagulation time | The time required for blood to coagulate; prolonged in haemophilia and in the presence of obstructive jaundice, some anaemias and leukaemias, and some of the infectious diseases. Synonym: clotting time. (05 Mar 2000) |
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| whole blood | <haematology> Blood that has not been separated into its various components. (13 Nov 1997) |
| exchange transfusion, whole blood | Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of foetal erythroblastosis, hepatic coma, sickle cell anaemia, disseminated intravascular coagulation, septicaemia, burns, thrombotic thrombopenic purpura, and fulminant malaria. (12 Dec 1998) |
| blood coagulation | The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. (12 Dec 1998) |
| blood coagulation factor inhibitors | Substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria. (12 Dec 1998) |
| blood coagulation factors | Endogenous substances, usually proteins, that participate in the blood coagulation process. (12 Dec 1998) |
| blood coagulation tests | Laboratory tests for evaluating the individual's clotting mechanism. (12 Dec 1998) |
| blood circulation time | Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points. (12 Dec 1998) |
| whole | 1. Containing the total amount, number, etc.; comprising all the parts; free from deficiency; all; total; entire; as, the whole earth; the whole solar system; the whole army; the whole nation. "On their whole host I flew unarmed." "The whole race of mankind." (Shak) 2. Complete; entire; not defective or imperfect; not broken or fractured; unimpaired; uninjured; integral; as, a whole orange; the egg is whole; the vessel is whole. "My life is yet whole in me." (2 Sam. I. 9) 3. Possessing, or being in a state of, heath and soundness; healthy; sound; well. "[She] findeth there her friends hole and sound." (Chaucer) "They that be whole need not a physician." (Matt. Ix. 12) "When Sir Lancelot's deadly hurt was whole." (Tennyson) Whole blood. The common snipe, as distinguished from the smaller jacksnipe. Synonym: All, total, complete, entire, integral, undivided, uninjured, unimpaired, unbroken, healthy. Whole, Total, Entire, Complete. When we use the word whole, we refer to a thing as made up of parts, none of which are wanting; as, a whole week; a whole year; the whole creation. When we use the word total, we have reference to all as taken together, and forming a single totality; as, the total amount; the total income. When we speak of a thing as entire, we have no reference to parts at all, but regard the thing as an integer, i. E, continuous or unbroken; as, an entire year; entire prosperity. When we speak of a thing as complete, there is reference to some progress which results in a filling out to some end or object, or a perfected state with no deficiency; as, complete success; a complete victory. "All the whole army stood agazed on him." (Shak) "One entire and perfect chrysolite." (Shak) "Lest total darkness should by night regain Her old possession, and extinguish life." (Milton) "So absolute she seems, And in herself complete." (Milton) Origin: OE. Hole, hol, hal, hool, AS. Hal well, sound, healthy; akin to OFries. & OS. Hl, D. Heel, G. Heil, Icel. Heill, Sw. Hel whole, Dan. Heel, Goth. Hails well, sound, OIr. Cl augury. Cf. Hale, Hail to greet, Heal to cure, Health, Holy. Source: Websters Dictionary (01 Mar 1998) |
| whole-arm fusion | <genetics, molecular biology> A break in the shortest arms of two acrocentric chromosomes followed by the fusion of the long arms into a single chromosome. (13 Nov 1997) |
| whole-body counter | Shielding and instrumentation, usually involving more than one detector, designed to evaluate the total-body burden of various gamma-emitting nuclides. (05 Mar 2000) |
| whole-body counting | Measurement of radioactivity in the entire human body. (12 Dec 1998) |
| whole-body irradiation | Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms. (12 Dec 1998) |
| whole-body titration curve | A graphic representation of the in vivo changes in hydrogen ion, PaCO2, and bicarbonate which occur in arterial blood in response to primary acid-base disturbances. (05 Mar 2000) |
| whole cell patch | <physiology> A variant of patch clamp technique, in which the patch electrode seals against the cell, with direct communication between the interior of the electrode and the cytoplasm. (18 Nov 1997) |