Von Hippel-Lindau Tumor Suppressor Protein - ț̢
A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
Synonyms : VHL Tumor Suppressor Protein, Von Hippel Lindau Tumor Suppressor Protein