| voltage gradient | <physiology> Literally, the electric field in a region, defined as the potential difference between two points divided by the distance between them. Used more loosely, the potential difference across a plasma membrane. (18 Nov 1997) |
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| voltage | <physics> Electric potential or potential difference, expressed in volts. Source: Websters Dictionary (01 Mar 1998) |
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| voltage clamp | <physiology, technique> A technique in electrophysiology, in which a microelectrode is inserted into a cell and current injected through the electrode so as to hold the cells membrane potential at some predefined level. The technique can be used with separate electrodes for voltage sensing and current passing, for small cells, the same electrode can be used for both. Voltage clamp is a powerful technique for the study of ion channels. See: patch clamp. (18 Nov 1997) |
| voltage-gated channel | A class of ion channel's that open and close in response to change in the electrical potential across the plasma membrane of the cell; voltage-gated Na+ c.'s are important for conducting action potential along nerve cell processes. (05 Mar 2000) |
| voltage gated ion channel | <physiology> A transmembrane ion channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. These channels are essential for neuronal signal transmission and for intracellular signal transduction. See: sodium channel. (18 Nov 1997) |
| voltage loop | <radiobiology> A wire which encircles the main axis of a tokamak in the vicinity of the vacuum vessel. The voltage induced in this loop during the shot is a measure of the ohmic heating voltage induced by transformer action and applied to the plasma. (09 Oct 1997) |
| atrioventricular gradient | The diastolic pressure difference between the atrium and ventricle. (05 Mar 2000) |
| magnetic field gradient | In magnetic resonance imaging, a magnetic field that varies with location, superimposed on the uniform field of the magnet, to alter the resonant frequency of nuclei and allow recovery of their spatial position. Synonym: field gradient. (05 Mar 2000) |
| ventricular gradient | The algebraic sum of (i.e., the net electrical difference between) the area enclosed within the QRS complex and that within the T wave in the electrocardiogram. (05 Mar 2000) |
| centrifugation, density gradient | Separation of particles according to density by employing a gradient of varying densities. at equilibrium each particle settles in the gradient at a point equal to its density. (12 Dec 1998) |
| cesium chloride gradient centrifugation | A type of density gradient centrifugation, a lab technique used to separate or purify nucleic acids. It involves putting cesium chloride and the nucleic acids into a centrifuge to be spun for hours or days. The cesium chloride forms a density gradient (highly dense at the bottom, thinnest at the top), and the different nucleic acids separate along the gradient according to their buoyancies in different densities. (09 Oct 1997) |
| gradient | <physics> Mathematical term for the operator which determines the magnitude and direction of the greatest rate-of-change of a given function with position. Similarly used to describe such a rate-of-change. For instance, at a given point on a hill, the slope of the hill in the steepest uphill direction is the gradient of the altitude function for the hill. (09 Oct 1997) |
| gradient elution | Elution in column chromatography in which a changing pH or ionic strength is used to separate substances. (05 Mar 2000) |
| gradient encoding | In magnetic resonance imaging, the technique of inducing a gradient in the magnetic field in the Y-axis to induce phase differences with location. Synonym: gradient encoding. (05 Mar 2000) |
| gradient perception | <cell biology> Problem faced by a cell that is to respond directionally to a gradient of, for example: a diffusible attractant chemical. In a spatial mechanism the cell would compare receptor occupancy at different sites on the cell surface, a temporal mechanism would involve comparison of concentrations at different times, the cell moving randomly between readings. In pseudospatial sensing, the cell would detect the gradient as a consequence of positive feedback to protrusive activity if receptor occupancy increased with time as the protrusion moved up gradient. Few cell types have been unambiguously shown to detect gradients. (18 Nov 1997) |
| mitral gradient | The diastolic pressure difference between the left atrium and left ventricle. (05 Mar 2000) |