| vitronectin |
a multifunctional adhesive glycoprotein occurring in serum and various tissues and having binding sites for integrins, collagen, heparin, complement components and perforin. Its functions include regulation of the coagulation, fibrinolytic, and complement cascades, and it plays a role in hemostasis, wound healing, tissue remodeling, and cancer. It binds plasminogen activator inhibitor (PAI-1); mediates the inflammatory and repair reactions occurring at sites of tissue injury; and promotes adhesion, spreading, and migration of cells. It has been shown to be identical to S protein, which was identified as an inhibitor of complement activation, binding the membrane attack complex and preventing its insertion into the membrane.
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