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vacuolar Relating to or resembling a vacuole.
(05 Mar 2000)
vacuolar ATPase <enzyme> From eukaryotic endomembrane systems, including vacuoles, lysosomes, golgi apparatus, chromaffin granules and coated vesicles. One of three major classes of ion transport ATPase, characterised by a multi subunit structure and a lack of a phosphorylated intermediate.
Found in archaebacteria but not eubacteria, in the intracellular acidic vacuoles and in some proton pumping epithelia (e.g. Intercalated cells of kidney). A complex enzyme encoded by several genes, involved in ion translocation but does not act via phosphorylated enzyme intermediate
See: P-type ATPase.
Registry number: EC 3.6.1.-
Synonym: atpase, v-type, atpase, vacuolar, vacuolar atpase, v-atpase, vacuolar h+-atpase, vacuolar membrane h(+)-atpase, vha55 gene product, vma16 gene product
(26 Jun 1999)
vacuolar calcium ATPase <enzyme> Isolated from saccharomyces cerevisiae; genbank u36603
Registry number: EC 3.6.1.-
Synonym: h(+)-ca(2+)-atpase, vacuolar
(26 Jun 1999)
vacuolar degeneration Formation of nonlipid vacuoles in cytoplasm, most frequently due to accumulation of water by cloudy swelling.
(05 Mar 2000)
vacuolar nephrosis Vacuolation of the epithelial cytoplasm of renal convoluted tubules in patients seriously depleted of potassium; vacuoles do not contain fat or glycogen, concentrating ability is impaired, polyuria and polydipsia are common, and pyelonephritis may develop.
Synonym: vacuolar nephrosis.
(05 Mar 2000)
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