| tyrocidine | <chemical> An antibiotic mixture produced by bacillus brevis which may be separated into three components, tyrocidines a, b, and c. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally. Pharmacological action: anti-infective agents, local, antibiotics, peptide. (12 Dec 1998) |
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| tyrocidine synthetase | <enzyme> Consists of 3 multifunctional enzymes involved in the biosynthesis of the cyclic decapeptide tyrocidine; tyrocidine synthetase 1 activates the phenylalanine and racemises it; tyrocidine sythetase 2 activates proline, phenylalanine and phenylalanine in positions 2,3 and 4 and racemises phenylalanine at position 4; tyrocidine synthetase 3 catalyses the activation of the remaining 6 amino acids; see also record for tyrocidine synthetase 1 Registry number: EC 6.3.2.- Synonym: tycb gene product, tycc gene product (26 Jun 1999) |