| type I acrocephalosyndactyly | <paediatrics> A usually inherited disorder characterised by premature closing of the cranial suture lines resulting in a peaked shaped head and abnormal facial appearance. Since it is usually autosomal dominant one or both parents also have the disorder. Surgery is used to correct skull and facial abnormalities. Inheritance: autosomal dominant. (29 Dec 1997) |
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| type I cells | Highly attentuated squamous cell's that form the gas-permeable epithelium lining the alveoli of the lungs. Synonym: type I cells. (05 Mar 2000) |
| type I collagen | The most abundant collagen, which forms large well-organised fibrils having high tensile strength. (05 Mar 2000) |
| type I diabetes | A chronic condition in which the pancreas makes little or no insulin because the beta cells have been destroyed. The body is then not able to use the glucose (blood sugar) for energy. IDDM usually comes on abruptly, although the damage to the beta cells may begin much earlier. The signs of IDDM are a great thirst, hunger, a need to urinate often, and loss of weight. To treat the disease, the person must inject insulin, follow a diet plan, exercise daily, and test blood glucose several times a day. IDDM usually occurs in children and adults who are under age 30. This type of diabetes used to be known as juvenile diabetes, juvenile-onset diabetes, and ketosis-prone diabetes. (09 Oct 1997) |
| type I diabetes mellitus | <endocrinology> A severe metabolic disorder which has an abrupt onset before the age of twenty. In it, an insulin deficiency prevents the body from using carbohydrates properly and forces it to rely mainly on protein metabolism. Treatment of the disease includes strict dietary regulation and mandatory insulin injections. (09 Oct 1997) |
| type I dip | Early deceleration of the foetal heart rate at the height of uterine contraction, as displayed on a foetal monitor graph. (05 Mar 2000) |
| type i error | The statistical error (said to be of the first kind or alpha error) made in testing an hypothesis when it is concluded that a treatment or intervention is effective when it really is not. Sometimes referred to as a false positive. (12 Dec 1998) |
| type I familial hyperlipoproteinaemia | Hyperlipoproteinaemia characterised by the presence of large amounts of chylomicrons and triglycerides in the plasma when the patient has a normal diet, and their disappearance on a fat-free diet; low alpha-and beta-lipoproteins on a normal diet, with increase on fat-free diet; decreased plasma postheparin lipolytic activity; and low tissue lipoprotein lipase activity. It is accompanied by bouts of abdominal pain, hepatosplenomegaly, pancreatitis, and eruptive xanthomas; autosomal recessive inheritance. See: familial lipoprotein lipase inhibitor. Synonym: Burger-Grutz syndrome, familial fat-induced hyperlipaemia, familial hyperchylomicronaemia, familial hypertriglyceridemia, idiopathic hyperlipaemia. (05 Mar 2000) |
| type I H/S mucopolysaccharidosis | <syndrome> Although clinically distinct diseases, fibroblasts from patients with Hurler syndrome and with Scheie syndrome do not cross complement in culture, suggesting that the enzyme defect is the same. (18 Nov 1997) |
| type I hyperlipoproteinaemia | <biochemistry> An rare inherited disorder where there is a deficiency of an enzyme (lipoprotein lipase) which breaks down fat molecules, causing the accumulation of fats or lipoproteins in the blood. Symptoms in infancy include abdominal pain (appears as if its colic), failure to thrive and skin lesions (xanthomas). Origin: Gr. Haima = blood (27 Sep 1997) |
| type I interferon | <chemical> Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (interferon-alpha and interferon-beta). Pharmacological action: antineoplastic agent, antiviral agents. (12 Dec 1998) |
| type I mortality | <epidemiology> A mortality schedule in which all hosts are assumed to live for a fixed number of years equal to the life expectancy. (05 Dec 1998) |
| type IH mucopolysaccharidosis | <syndrome> Mucopolysaccharidosis in which there is a deficiency of alpha-l-iduronidase, an accumulation of an abnormal intracellular material, and excretion of dermatan sulfate and heparan sulfate in the urine; with severe abnormality in development of skeletal cartilage and bone, with dwarfism, kyphosis, deformed limbs, limitation of joint motion, spadelike hand, corneal clouding, hepatosplenomegaly, mental retardation, and gargoyle-like facies; autosomal recessive inheritance. See: mucolipidosis. Synonym: dysostosis multiplex, Hurler's disease, lipochondrodystrophy, Pfaundler-Hurler syndrome, type IH mucopolysaccharidosis. (05 Mar 2000) |
| type II acrocephalosyndactyly | type II acrocephalosyndactyly |
| type II cells | Cuboidal cell's connected with the squamous pulmonary alveolar cell's and having in their cytoplasm lamellated bodies (cytosomes) that represent the source of the surfactant that coats the alveoli. Synonym: granular pneumonocytes, type II cells. (05 Mar 2000) |
| acrocephalosyndactyly type 1 | <paediatrics> An inherited disease (autosomal dominant) or a spontaneously occurring disease characterised by a peaked head and unusual facial appearance, due to the premature closure of the cranial sutures. A skull X-ray can confirm the diagnosis and treatment is surgical. Inheritance: autosomal dominant. (27 Sep 1997) |
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| Alzheimer type I astrocyte | Enlarged frequently multinucleated astrocytes, seen in progressive multifocal leukoencephalopathy. (05 Mar 2000) |
| Alzheimer type II astrocyte | Enlarged astrocytes with vesicular nuclei and one or more small basophilic nucleoli, seen in hepatocerebral disease and Wilson's disease. (05 Mar 2000) |
| American Type Culture Collection | <cell culture> A key resource for cultured cells, located in Rockville, USA. (12 Dec 1998) |
| Antoni type A neurilemoma | <tumour> Relatively solid or compact arrangement of neoplastic tissue that consists of Schwann cells arranged in twisting bundles and associated with delicate reticulin fibres; the nuclei of the Schwann cells are frequently grouped in parallel rows (so-called palisades), and the nuclei and fibres sometimes form exaggerated tactile corpuscles, called Verocay bodies. (05 Mar 2000) |
| Antoni type B neurilemoma | <tumour> Relatively soft or loose arrangement of neoplastic tissue that consists of Schwann cells in a haphazard or nondescript type of arrangement among reticulin fibres and tiny cystlike foci; fat-laden macrophages may be observed in some of the larger neoplasms. (05 Mar 2000) |
| arthus-type reaction's | Reaction's in man and other species that result from the same basic immunologic (allergic) mechanism which evokes, in the rabbit, the typical Arthus phenomenon. See: immune complex disease. (05 Mar 2000) |
| avian adenovirus type 1 proteinase | <enzyme> 206 aa residues of which 66% are homologous to human ad2 emzyme embl/genbank l13161 Registry number: EC 3.4.22.- Synonym: aavl proteinase, aavl endopeptidase (26 Jun 1999) |
| basic personality type | An individual's unique, covert, or underlying personality propensities, whether or not they are behaviourally manifest or overt, personality characteristics of an individual which are also shared by a majority of the members of a social group. (05 Mar 2000) |
| Becker type muscular dystrophy | A muscular dystrophy that has many of the clinical features of Duchenne muscular dystrophy e.g., symmetrical involvement of first the pelvicrural muscles and then the pectoral girdle and proximal upper extremity muscles; pseudohypertrophy, especially of the calf muscles but with a much later age of onset (35-45 years), and more benign course. X-linked inheritance. (05 Mar 2000) |
| Becker type tardive muscular dystrophy | Muscular dystrophy of late onset, often in the second or third decade, with relatively mild course; X-linked recessive inheritance; perhaps allelic with Duchenne's dystrophy, but milder and not a genetic lethal. Compare: Duchenne dystrophy. Synonym: Becker type tardive muscular dystrophy. (05 Mar 2000) |
| blood type | The specific reaction pattern of erythrocytes of an individual to the antisera of one blood group; e.g., the ABO blood group consists of four major blood types: O, A, B, and AB. This classification depends on the presence or absence of two major antigens: A or B. Type O occurs when neither is present and type AB when both are present. The blood type is the genetic phenotype of the individual for one blood group system and may be determined using different antisera available for testing. See Blood Groups appendix. (05 Mar 2000) |
| Borst-Jadassohn type intraepidermal epithelioma | <tumour> Precancerous lesions clinically suggestive of actinic or seborrheic keratosis, with nests of immature or abnormal keratinocytes within the epidermis. (05 Mar 2000) |
| botulinum toxin type a | <chemical> A neurotoxin produced by clostridium botulinum. When consumed in contaminated food it can cause paralysis and death. In its purified form, it has been used in the treatment of blepharospasm and strabismus. Pharmacological action: neuromuscular agents. (12 Dec 1998) |
| bovine adenovirus type 3 proteinase | <enzyme> Amino acid sequence given in first source Registry number: EC 3.4.- Synonym: bav-3 proteinase (26 Jun 1999) |