| tropine | <chemistry> A white crystalline alkaloid, C8H15NO, produced by decomposing atropine. Origin: From Atropine. Source: Websters Dictionary (01 Mar 1998) |
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| tropine dehydrogenase | <enzyme> A stereospecific reductase; catalyses the reduction of tropinone to tropine (tropan-3alpha-ol); shares 64% amino acid sequence identity with tropinone reductase II, the pseudotropine-forming reductase Registry number: EC 1.1.1.206 Synonym: tropine-forming reductase, tropinone reductase i (26 Jun 1999) |
| tropine mandelate | <medicine> An alkaloid, prepared from atropine, and from other sources. It is chemically related to atropine, and is used for the same purpose. Origin: Homo- + atropine. Source: Websters Dictionary (01 Mar 1998) |
| tropine tropate | <drug> A toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms. Pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and AV conduction. Uses: Treat bradycardia, asystole, and AV block Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects Atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 mL sterile water or normal saline. Potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium Note: The denervated heart will not respond to atropine. (15 Mar 2000) |