| transcriptase | <enzyme> RNA directed DNA polymerase. Enzyme first discovered in retroviruses, that can construct double stranded DNA molecules from the single stranded RNA templates of their genomes. Reverse transcription now appears also to be involved in movement of certain mobile genetic elements, such as the Ty plasmid in yeast, in the replication of other viruses such as Hepatitis B and possibly in the generation of mammalian pseudogenes. (18 Nov 1997) |
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| reverse transcriptase | <enzyme> RNA directed DNA polymerase. Enzyme first discovered in retroviruses, that can construct double stranded DNA molecules from the single stranded RNA templates of their genomes. Reverse transcription now appears also to be involved in movement of certain mobile genetic elements, such as the Ty plasmid in yeast, in the replication of other viruses such as Hepatitis B and possibly in the generation of mammalian pseudogenes. (18 Nov 1997) |
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| reverse transcriptase inhibitors | Inhibitors of reverse transcriptase (RNA-directed DNA polymerase), an enzyme that synthesises DNA on an RNA template. (12 Dec 1998) |
| reverse transcriptase md | <molecular biology> A viral enzyme that constructs DNA from an RNA template, which is an essential step in the life-cycle of a retrovirus such as HIV (09 Oct 1997) |
| reverse transcriptase PCR | A technique used to amplify RNA targets. The specimen containing the target RNA (e.g., HIV-1 RNA, Hepatitis C Virus RNA) is subjected to reverse transcription to make complementary DNA (cDNA), which is then, in turn, amplified by PCR. Acronym: RT-PCR (05 Mar 2000) |
| HIV-1 reverse transcriptase | <enzyme> HIV-1 enzyme responsible for the synthesis of DNA from genomic RNA of the virus. It is encoded by the pol gene of HIV-1. Registry number: EC 2.7.7.- (12 Dec 1998) |
| HIV-2 reverse transcriptase | <enzyme> Responsible for synthesis of double-stranded DNA from the genomic RNA of the virus; has rnase h and DNA-dependent DNA polymerase activities; was indexed as reverse transcriptase (87-91) Registry number: EC 2.7.7.- (26 Jun 1999) |