| thyroid stimulating antibody | <endocrinology, immunology> Long acting thyroid stimulator is an autoantibody found in many cases of primary thyrotoxicosis which causes hyperplasia of the thyroid by undetermined mechanisms. Human thyroid stimulating immunoglobulin is a different antibody found in all or nearly all cases of primary thyrotoxicosis and may act by binding to the thyrotropin (TSH) receptor site, causing increased synthesis of thyroglobulin. (18 Nov 1997) |
|---|
| hormone, thyroid stimulating | A hormone produced by the pituitary gland (at the base of the brain) that promotes the growth of the thyroid gland (in the neck) and stimulates it to produce its thyroid hormones. Normally, the rate of thyroid hormone production is controlled by the pituitary. When there are insufficient thyroid hormones in the body for normal functioning of the cells, the pituitary releases tsh. Tsh in turn stimulates the thyroid gland to produce more thyroid hormones. In contrast, when there is excessive amount of thyroid hormones, the pituitary gland stops producing tsh. The tsh level then falls and thyroid hormone production is reduced. This mechanism maintains a relatively constant level of thyroid hormones circulating in the blood. This phenomenon is analogous to a thermostat used for temperature regulation in a room: when the temperature rises, the thermostat shuts the heater off and the room temperature falls back to normal. High levels of thyroid hormones cause the tsh level to fall, resulting in no further stimulation of the thyroid gland. In hyperthyroidism, there are continuously elevated levels of the thyroid hormones. Tsh is also known as thyrotropin. (12 Dec 1998) |
|---|---|
| immunoglobulins, thyroid-stimulating | Autoantibodies that bind to the thyroid-stimulating hormone (tsh) receptor (receptors, thyrotropin) on thyroid epithelial cells. The autoantibodies mimic tsh causing an unregulated production of thyroid hormones characteristic of graves' disease. (12 Dec 1998) |
| thyroid stimulating hormone | <endocrinology> Polypeptide hormone (28 kD), secreted by the anterior pituitary gland, that activates cyclic AMP production in thyroid cells leading to production and release of the thyroid hormones (T4 and T3). T4 and T3 blood levels feedback on the pituitary gland and decrease thyroid stimulating hormone production when T3 and T4 levels are high. (27 Sep 1997) |
| thyroid-stimulating hormone | thyroid stimulating hormone |
| thyroid-stimulating hormone-releasing factor | <protein> See thyrotrophic releasing hormone. (18 Nov 1997) |
| thyroid-stimulating hormone stimulation test | TSH stimulating test, a test that measures the uptake of 131I in the thyroid gland before and after administration of thyroid-stimulating hormone; useful in distinguishing primary hyperthyroidism (increased TSH serum concentration) from secondary or tertiary hyperthyroidism (low TSH serum concentrations). (05 Mar 2000) |
| thyroid stimulating immunoglobulin | <protein> A test that measures the amount of an antibody (thyroid stimulating antibody) which is directed against a receptor for TSH on the thyroid gland. This antibody acts like TSH and stimulates the thyroid to produce excessive amounts of thyroid hormone. The presence of this antibody generally indicates Grave's disease (hyperthyroidism). (27 Sep 1997) |
| thyroid-stimulating immunoglobulins | In Graves' disease, the antibodies to TSH receptors in the thyroid gland. These antibodies are produced by B-lymphocytes and stimulate the receptors, causing hyperthyroidism. Formerly known as LATS (long-acting thyroid stimulator). (05 Mar 2000) |
| thyroid receptor antibody | A test that measures the amount of an antibody (thyroid stimulating antibody) which is directed against a receptor for TSH on the thyroid gland. This antibody acts like TSH and stimulates the thyroid to produce excessive amounts of thyroid hormone. The presence of this antibody generally indicates Grave's disease (hyperthyroidism). (27 Sep 1997) |
| adrenal androgen-stimulating hormone | A putative pituitary hormone that may be responsible for increased secretion of adrenal androgens at the time of puberty. (05 Mar 2000) |
| macrophage colony-stimulating factor | <growth factor> A glycoprotein growth factor that causes the committed cell line to proliferate and mature into macrophages. A cytokine synthesised by mesenchymal cells that stimulates pluripotent stem cells of bone marrow into differentiating towards the production of monocytes (mononuclear phagocytes). The compound stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. It is a disulfide-bonded glycoprotein dimer with a mw of 70 kD and binds to a single class of high affinity receptor which is identical to the product of the c-fms proto-oncogene. See: colony-stimulating factors. Chemical name: Colony-stimulating factor 1 Acronym: M-CSF (12 Dec 1998) |
| receptors, colony-stimulating factor | Cell surface receptors for colony-stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of haemopoietic cells. (12 Dec 1998) |
| receptors, granulocyte-colony-stimulating factor | Receptors that bind and internalise granulocyte-colony-stimulating factor. Their mw is believed to be 150 kD. These receptors are found mainly on a subset of myelomonocytic cells. (12 Dec 1998) |
| receptors, granulocyte-macrophage colony-stimulating factor | Receptors that bind and internalise the granulocyte-macrophage stimulating factor. Their mw is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor. (12 Dec 1998) |
| receptors, macrophage colony-stimulating factor | Glycoproteins of mw 165 kD which are encoded by the c-fms proto-oncogene. The binding of csf-1 to its receptors activates an intrinsic tyrosine kinase activity resulting in autophosphorylation of the receptors on tyrosine, rapid receptor down-regulation, and phosphorylation of as yet unidentified physiologic substrates that initiate a mitogenic response. (12 Dec 1998) |