| purpura, thrombotic thrombocytopenic | A disease characterised by thrombocytopenia, haemolytic anaemia, bizarre neurological manifestations, azotemia, fever, and thromboses in terminal arterioles and capillaries. (12 Dec 1998) |
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| thrombotic thrombocytopenic purpura | A rapidly fatal or occasionally protracted disease with varied symptoms in addition to purpura, including signs of central nervous system involvement, due to formation of fibrin or platelet thrombi in arterioles and capillaries in many organs. Synonym: Moschcowitz' disease. (05 Mar 2000) |
| abacterial thrombotic endocarditis | Verrucous endocardial lesions occurring in the terminal stages of many chronic infectious and wasting diseases. Synonym: abacterial thrombotic endocarditis, cachectic endocarditis, terminal endocarditis, thromboendocarditis. (05 Mar 2000) |
| nonbacterial thrombotic endocarditis | Verrucous endocardial lesions occurring in the terminal stages of many chronic infectious and wasting diseases. Synonym: abacterial thrombotic endocarditis, cachectic endocarditis, terminal endocarditis, thromboendocarditis. (05 Mar 2000) |
| thrombotic | Relating to, caused by, or characterised by thrombosis. (05 Mar 2000) |
| thrombotic disease due to protein c deficiency | Protein C is a protein in plasma that enters into the cascade of biochemical events leading to the formation of a clot. Deficiency of protein c results in thrombotic (clotting) disease and excess platelets with recurrent thrombophlebitis (inflammation of the vein that occurs when a clot forms). The clot can break loose and travel through the blood stream (thromboembolism) to the lungs causing a pulmonary embolism, brain causing a stroke (cerebrovascular accident), heart causing an early heart attack, skin causing what in the newborn is called neonatal purpura fulminans, the adrenal gland causing haemorrhage with abdominal pain, abnormally low blood pressure (hypotension), and salt loss. Protein c deficiency is due to possession of one gene (heterozygosity) in chromosome band 2q13-14. The possession of two such genes (homozygosity) is usually lethal. (12 Dec 1998) |
| thrombotic gangrene | Gangrene due to occlusion of an artery by a thrombus. (05 Mar 2000) |
| thrombotic hydrocephalus | Increase in cerebrospinal fluid and of intracranial pressure following thrombosis of the cerebral veins or sinuses; caused by septic infection, dehydration, tuberculosis, typhoid, leukaemia, and other conditions. (05 Mar 2000) |
| thrombotic infarct | An infarct caused by a thrombus. (05 Mar 2000) |
| thrombotic microangiopathy | Thrombosis within small blood vessels, as in thrombotic thrombocytopenic purpura. (05 Mar 2000) |
| thrombotic phlegmasia | An extreme edematous swelling of the leg following childbirth, due to thrombosis of the iliofemoral veins. Synonym: leukophlegmasia dolens, milk leg, puerperal phlebitis, thrombotic phlegmasia, white leg. (05 Mar 2000) |
| acute vascular purpura | <dermatology> This relatively rare disorder is characterised by skin purpura, joint pains, abdominal pain and renal disease (glomerulonephritis). Although Henoch-Schonlein purpura or anaphylactoid purpura, is thought to be a immune complex mediated disease, its exact cause is unknown. Its typical benign coarse can, however, include renal failure. (27 Sep 1997) |
| allergic purpura | Nonthrombocytopenic purpura due to sensitization to foods, drugs, and insect bites. Synonym: anaphylactoid purpura. (05 Mar 2000) |
| anaphylactoid purpura | <dermatology> This relatively rare disorder is characterised by skin purpura, joint pains, abdominal pain and renal disease (glomerulonephritis). Although Henoch-Schonlein purpura or anaphylactoid purpura, is thought to be a immune complex mediated disease, its exact cause is unknown. Its typical benign coarse can, however, include renal failure. (27 Sep 1997) |
| autoimmune thrombocytopenia purpura | <haematology> A rare autoimmune disorder characterised by an acute shortage of platelets with resultant bruising and spontaneous bleeding. The platelet count becomes exceedingly low and spontaneous bleeding from the gums, gastrointestinal tract and nose can be seen. Physical examination may demonstrate enlargement of the spleen. A typical rash occurs to do microscopic haemorrhage of small blood vessels in the skin. Platelet counts under 10,000 can lead to spontaneous haemorrhage into the brain causing death. Treatment with corticosteroids is generally effective. Surgical removal of the spleen (splenectomy) is reserved for some patients. Anti-platelet antibodies are detectable in some cases. It may present in either an acute or a chronic form. Acronym: ITP (20 Sep 2002) |