| thrombospondin | <cell biology> Homotrimeric glycoprotein (450 kD) from _ granules of platelets and synthesised by various cell types in culture. Also found in extracellular matrix of cultured endothelial, smooth muscle and fibroblastic cells. May have autocrine growth regulatory properties: involved in platelet aggregation. (18 Nov 1997) |
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| thrombospondin 1 | An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumour growth and metastasis. (12 Dec 1998) |
| thrombospondins | A family of related, adhesive glycoproteins which are synthesised, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of blood coagulation factors and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (comp). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumour metastasis, vascular smooth muscle growth, and tissue repair. (12 Dec 1998) |