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thrombi Plural of thrombus.
(05 Mar 2000)
thrombin <enzyme> Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly.
Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion.
(18 Nov 1997)
thrombin time Test of the conversion of fibrinogen to fibrin by thrombin in which clotting time of plasma mixed with a thrombin solution is measured. Time is prolonged by afibrinogenaemia, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, heparin. Reptilase, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
(12 Dec 1998)
thrombinogen A coagulation factor needed for the normal clotting of blood. In the cascade of events leading to the final clot, thrombinogen precedes thrombin (and so is a precursor to thrombin). In fact, thrombinogen gives rise to thrombin, and also called prothrombin.
(12 Dec 1998)
thrombinogenesis Thrombin production.
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 2 ÆäÀÌÁö: 1
  • Thrombin - »õâ An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
    Synonyms : Thrombinar, Thrombostat, alpha-Thrombin, beta, gamma-Thrombin, beta-Thrombin, gamma-Thrombin
  • Thrombin Time - »õâ Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
    Synonyms : Reptilase Times, Thrombin Times, Time, Reptilase, Time, Thrombin, Times, Reptilase, Times, Thrombin
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thrombi plural of thrombus.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
thrombin 1. the activated form of coagulation factor II (prothrombin); it converts fibrinogen to fibrin. Called also fibrinogenase and thrombase.  2.  [USP] a sterile protein substance (topical t.) prepared from prothrombin of bovine origin through interaction with added thromboplastin in the presence of calcium; used therapeutically as a local hemostatic.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
thrombin t. the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured; it is prolonged with abnormalities of fibrinogen and in the presence of heparin or of fibrin/fibrinogen degradation products.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
Thrombin-JMI trademark for preparations of thrombin of bovine origin.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
thrombinogen factor II; see under coagulation factors, at factor.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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