| thiol | 1. The monovalent radical -SH when attached to carbon; a hydrosulfide; a mercaptan. 2. A mixture of sulfurated and sulfonated petroleum oils purified with ammonia; used in the treatment of skin diseases. (05 Mar 2000) |
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| thiol activated haemolysins | Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function. Oxidation (to disulphide bridges) inactivates the toxin. Examples: tetanolysin, streptolysin O, _ toxin, cereolysin. (18 Nov 1997) |
| thiol beta-lactamase | <enzyme> Active site serine has been mutated to cysteine in e. Coli Registry number: EC 3.5.2.- (26 Jun 1999) |
| thiol endopeptidase | Proteases that have an active thiol group. Includes papain and ficin. (18 Nov 1997) |
| thiol enzyme | <enzyme> An enzyme whose activity depends on a free thiol group. (05 Mar 2000) |
| thiol ester | An ester formed from a carboxylic acid and a thiol (i.e., RCO-SR') e.g., acetyl-coenzyme A. (05 Mar 2000) |
| thiol proteinase | Proteases that have an active thiol group. Includes papain and ficin. (18 Nov 1997) |
| thiol-dependent peroxidase | <enzyme> From giardia intestinalis, which lacks glutathione; enzyme can also act with exogenous glutathione Registry number: EC 1.11.1.- Synonym: glutathione-linked thiol peroxidase (26 Jun 1999) |
| thiolase | An acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis. Synonym: acetoacetyl-CoA thiolase, acetyl-CoA thiolase, thiolase. (05 Mar 2000) |
| thiole | <chemistry> A sulphur hydrocarbon, C4H4S, analogous to furfuran and benzene, and acting as the base of a large number of substances which closely resemble the corresponding aromatic derivatives. Origin: Thio- + phenyl + -ene. Source: Websters Dictionary (01 Mar 1998) |
| thiolester hydrolases | <enzyme> Registry number: EC 3.1.2. (12 Dec 1998) |
| thiolesterase | <enzyme> An enzyme that hydrolyzes thioesters; e.g., the deacylating activity at the end of fatty acid biosynthesis that releases palmitate. Synonym: thiolesterase. (05 Mar 2000) |
| thiolhistidylbetaine | <chemical> Chemical name: 1H-Imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, inner salt, (S)- (12 Dec 1998) |
| thioltransacetylase A | <enzyme> Part of the pyruvate dehydrogenase complex; acef isolated from e. Coli Registry number: EC 2.3.1.12 Synonym: dihydrolipoyl transacetylase, lipoate acetyltransferase, dihydrolipoyl acetyltransferase, acef gene product (26 Jun 1999) |
| thioltransferase | <enzyme> Reduces disulfide groups via thiol transfer; proposed to catalyze transfer of organomercurial from one thiol complex to another Registry number: EC 1.8.4.1 Synonym: glutathione-disulfide oxidoreductase, thioldisulfide oxidoreductase, glutaredoxin, mammalian, glutaredoxin, rice (26 Jun 1999) |
| PepC thiol aminopeptidase | <enzyme> A hexameric protein; isolated from lactoccocus lactis; homologous to bleomycin hydrolase; has been sequenced Registry number: EC 3.4.11.- Synonym: thiol aminopeptidase pepc, pepc cysteine aminopeptidase (26 Jun 1999) |
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| prohormone thiol protease | <enzyme> Catalyses the final step of (met)enkephalin sythesis in chromaffin granules Registry number: EC 3.4.22.- (26 Jun 1999) |
| O-acetylhomoserine (thiol)-lyase | <enzyme> With hydrogen sulfide, forms homocysteine Registry number: EC 4.2.99.10 Synonym: acetylhomoserine sulfhydrylase, homocysteine synthase, oah sulfhydrylase, o-acetylhomoserine sulfhydrylase, o-acetyl-l-homoserine sulfhydrylase, o-acetylhomoserine-o-acetylserine sulfhydrylase, met25 sulfhydrylase, o-acetylserine-o-acetylhomoserine sulfohydro-lyase, aahshase (26 Jun 1999) |
| O-succinylhomoserine (thiol)-lyase | <enzyme> An enzyme catalyzing the reaction between cystathionine and succinate to form l-cysteine and O-succinyl-l-homoserine. Synonym: cystathionine gamma-synthase. (05 Mar 2000) |