| thiamine pyrophosphate | <biochemistry> Co carboxylase. A cofactor that has an unusually acidic carbon atom able to form carbon carbon bonds. Found in pyruvate dehydrogenase and transketolase. (18 Nov 1997) |
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| thiamine | <chemical> 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride (12 Dec 1998) |
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| thiamine deficiency | A nutritional condition produced by a deficiency of thiamine in the diet, characterised by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the united states most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, beriberi prevalence is very high. (12 Dec 1998) |
| thiamine monophosphate | <chemical> Thiamine dihydrogen phosphate ester. The monophosphate ester of thiamine. Synonym: monophosphothiamine; vitamin b1 monophosphate. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(2-(phosphonooxy)ethyl)-, chloride (12 Dec 1998) |
| thiamine pyrophosphatase | <enzyme> The coenzyme form of vitamin B1 (thiamine), deficiency of which causes beri beri. Forms the prosthetic group of pyruvate dehydrogenase, _ ketoglutarate dehydrogenase and transketolase, in which it is involved in transfer of a 2 carbon unit. Marker for the trans cisternae of the Golgi complex. (18 Nov 1997) |
| thiamine triphosphate | <chemical> 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)thiazolium hydroxide, inner salt, p,p',p''-trioxide. The triphosphate ester of thiamine. In leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation. Chemical name: Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)-, inner salt, P,P',P''-trioxide (12 Dec 1998) |
| alpha-hydroxyethylthiamin pyrophosphate | The activated form of acetaldehyde that is formed during the decarboxylation of active pyruvate. Formed in alcohol fermentation and in carbohydrate metabolism. Synonym: a-hydroxyethylthiamin pyrophosphate. (05 Mar 2000) |
| alpha-lactyl-thiamin pyrophosphate | An intermediate formed in the oxidative decarboxylation of pyruvate. Compare: pyruvate dehydrogenase (lipoamide). Synonym: alpha-lactyl-thiamin pyrophosphate. (05 Mar 2000) |
| aneurine pyrophosphate | The diphosphoric ester of thiamin, a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. Synonym: aneurine pyrophosphate, cocarboxylase, diphosphothiamin. (05 Mar 2000) |
| calcium pyrophosphate | <chemical> Diphosphoric acid, calcium salt. An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably hypophosphatasia and pseudogout. Chemical name: Diphosphoric acid, calcium salt (12 Dec 1998) |
| calcium pyrophosphate deposition disease | <radiology> Manifestations can occur singly or in any combination, pseudogout, acute crystal-induced synovitis with clinical symptoms analogous to gout, arthropathy, beaklike osteophytes of 2nd, 3rd metacarpal heads, subchondral cysts (especially carpal bones), unusual distribution of disease (radiocarpal/ulnar joint, patellofemoral joint), SLAC - scapholunate advanced collapse, chondrocalcinosis, triangular fibrocartilage, symphysis pubis, menisci of knee, annulus fibrosus of intervertebral disk (12 Dec 1998) |
| geranylgeranyl pyrophosphate | A key intermediate in the biosynthesis of many terpenes. (05 Mar 2000) |
| geranyl pyrophosphate | A key intermediate in the biosynthesis of sterols, dolichols, ubiquinone, and prenylated proteins. (05 Mar 2000) |
| geranyl pyrophosphate-sabinene hydrate cyclase | <enzyme> Enzyme from sweet marjoram; catalyses cation-dependent cyclization of geranyl pyrophosphate to cis and trans sabinene hydrate, deriving oh from water, not from the pyrophosphate ester Registry number: EC 5.5.- Synonym: sabinene hydrate cyclase, sabinene hydrate synthase (26 Jun 1999) |
| phosphoribosyl pyrophosphate | <chemical> The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. Chemical name: alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) (12 Dec 1998) |
| prelycopersene pyrophosphate synthetase | <chemical> Synonym: prephytoene pyrophosphate synthetase, prephytoene synthase (26 Jun 1999) |