| pulmonary surfactants | Lipoproteins in which the lipid moiety is based mainly on lecithin and other phospholipids. They may also contain small amounts of prostaglandins and other compounds. Composition is species dependent. They are secreted by the mitochondria of type II alveolar cells. Surfactants regulate the surface tension of the mucoid layer lining the alveoli. Absence of the surfactants in premature infants results in hyaline membrane disease and in adults in atelectasis. Synthetic pulmonary surfactants have also been prepared and are used therapeutically. (12 Dec 1998) |
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