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CNP community nurse practitioner; continuous negative pressure; cranial nerve palsy; 2',3'-cyclic nucleo...
PAF paroxysmal atrial fibrillation; peroxisomal assembly factor; phosphodiesterase-activating factor; pl...
PDEB phosphodiesterase beta
PDEG phosphodiesterase gamma
PDIE phosphodiesterase
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L/S Lecithin-Sphingomyelin
L/S lecithin/sphingomyelin ration
L/S ratio Lecithin/sphingomyelin ratio
SM Sphingomyelin
SP Sphingomyelin
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sphingomyelin phosphodiesterase <enzyme> An enzyme that catalyses the hydrolysis of sphingomyelin to ceramide (n-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to niemann-pick disease.
Chemical name: Sphingomyelin cholinephosphohydrolase
Registry number: EC 3.1.4.12
(12 Dec 1998)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
sphingomyelin <biochemistry> A sphingolipid in which the head group is phosphoryl choline. A close analogue of phosphatidylcholine. In many cells the concentration of sphingomyelin and phosphatidylcholine in the plasma membrane seems to bear a reciprocal relationship.
(18 Nov 1997)
sphingomyelin deacylase <enzyme> Forms sphingosylphosphocholine
Registry number: EC 3.5.1.-
Synonym: sm-deacylase
(26 Jun 1999)
sphingomyelin lipidosis <disease> A family of severe lysosomal storage diseases resulting in an accumulation of sphingomyelin and other phospholipids in the reticuloendothelial system.
The best studied forms are due to deficiency of sphingomyelinase and it is more common in Ashkenazi Jews than other groups.
Clinical signs include foam cells in the blood and marrow, hepatosplenomegaly and neurologic degeneration. Diagnosis is confirmed by enzyme assay on leukocytes or fibroblasts and specific mutations in the gene are now recognised.
(29 Dec 1997)
lecithin/sphingomyelin ratio A ratio used to determine foetal pulmonary maturity, found by testing the amniotic fluid; when the lungs are mature, lecithin exceeds sphingomyelin by 2 to 1.
(05 Mar 2000)
adenosine 3',5'-cyclic phosphate phosphodiesterase <enzyme> An enzyme that catalyses the hydrolysis of adenosine 3',5'-cyclic phosphate forming 5'-AMP. A crucial step in the regulation of cellular adenosine 3',5'-cyclic phosphate levels. Inhibited by caffeine.
Synonym: cAMP phosphodiesterase.
(05 Mar 2000)
alkylglycerophosphoethanolamine phosphodiesterase <enzyme> From microsomal preparations of rabbit kidney medulla; hydrolyzes choline moiety from lyso-paf to form 1-alkyl-2-lysoglycerophosphate in rat brain and other tissue; only lysoglycerophospholipids with ether linkages at the sn-1 position serve as substrates; acyl analogs are not utilised; requires magnesium
Registry number: EC 3.1.4.39
Synonym: lysophospholipase d
(26 Jun 1999)
calcium-calmodulin-dependent phosphodiesterase <enzyme> Hydrolyzes both cgmp and camp; induced during mitogenesis
Registry number: EC 3.1.4.-
Synonym: ca-cam-phosphodiesterase, calmodulin-dependent cgmp phosphodiesterase
(26 Jun 1999)
cAMP phosphodiesterase <enzyme> An enzyme that catalyses the hydrolysis of adenosine 3',5'-cyclic phosphate forming 5'-AMP. A crucial step in the regulation of cellular adenosine 3',5'-cyclic phosphate levels. Inhibited by caffeine.
Synonym: cAMP phosphodiesterase.
(05 Mar 2000)
gamma subunit, cGMP phosphodiesterase <enzyme> Isolated from canine retinal rod photoreceptor cells; genbank u49359
Registry number: EC 3.1.14.-
Synonym: pde-gamma, pdegamma, cgmp-pde gamma subunit
(26 Jun 1999)
PDE4D3 phosphodiesterase <enzyme> One of three variants encoded by pde4d gene; this form is expressed in rat thyroid cells
Registry number: EC 3.1.4.-
(26 Jun 1999)
glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase <enzyme> Removes the glucose-1-phosphate from glc-alpha-1-p-6-mannose residues in glycoproteins as a unit; pH optimum 7.5
Registry number: EC 3.1.4.51
Synonym: ag1p phosphodiesterase, alpha-glucose-1-phosphate phosphodiesterase
(26 Jun 1999)
glycerophosphodiester phosphodiesterase <enzyme> E coli enzyme; acts on variety of substrates to give glycerol-3-phosphate plus an alcohol, such as ethanolamine, choline, glycerol or glycerophosphoglycerol
Registry number: EC 3.1.4.46
Synonym: gpde-phosphodiesterase, glycerophosphosphoryl diester phosphodiesterase
(26 Jun 1999)
phosphodiesterase <enzyme> An enzyme that cleaves phosphodiesters to give a phosphomonoester and a free hydroxyl group.
Examples include RNase, DNase, phospholipases C and D and the enzymes that convert cyclic nucleotides to the monoester forms. In casual usage the cAMP phosphodiesterase is usually meant.
(18 Nov 1997)
phosphodiesterase inhibitors Compounds which inhibit or antagonise the biosynthesis or actions of phosphodiesterases.
(12 Dec 1998)
phosphodiesterase-phosphomonoesterase <enzyme> From fusarium moniliforme; hydrolyzes both phosphodiesters and phosphomonoesters
Registry number: EC 3.1.-
Synonym: pdmase
(26 Jun 1999)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 1 ÆäÀÌÁö: 1
  • Sphingomyelin Phosphodiesterase - »õâ An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
    Synonyms : Sphingomyelinase C
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sphingomyelin phosphodiesterase [EC 3.1.4.12] an enzyme of the hydrolase class that catalyzes the cleavage of sphingomyelin to ceramide and phosphorylated choline in the major pathway for sphingomyelin degradation. Deficiency of the enzyme, an autosomal recessive trait, causes Niemann-Pick disease. Called also sphingomyelinase.
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