| sialidase |
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of the enzyme, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. In EC nomenclature, called exo-α-sialidase. 2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.
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