| Berk Sharp technique | <molecular biology, procedure> A technique of genetic mapping in which mRNA is hybridised with single stranded DNA and the nonhybridised DNA then digested with S1 nuclease, the residual DNA that hybridised with the messenger is then characterised by restriction mapping. (18 Nov 1997) |
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| sharp | 1. Having a very thin edge or fine point; of a nature to cut or pierce easily; not blunt or dull; keen. "He dies upon my scimeter's sharp point." (Shak) 2. Terminating in a point or edge; not obtuse or rounded; somewhat pointed or edged; peaked or ridged; as, a sharp hill; sharp features. 3. Affecting the sense as if pointed or cutting, keen, penetrating, acute: to the taste or smell, pungent, acid, sour, as ammonia has a sharp taste and odour; to the hearing, piercing, shrill, as a sharp sound or voice; to the eye, instantaneously brilliant, dazzling, as a sharp flash. 4. High in pitch; acute; as, a sharp note or tone. Raised a semitone in pitch; as, C sharp (C#), which is a half step, or semitone, higher than C. So high as to be out of tune, or above true pitch; as, the tone is sharp; that instrument is sharp. Opposed in all these senses to flat. 5. Very trying to the feelings; pierching; keen; severe; painful; distressing; as, sharp pain, weather; a sharp and frosty air. "Sharp misery had worn him to the bones." (Shak) "The morning sharp and clear." (Cowper) "In sharpest perils faithful proved." (Keble) 6. Cutting in language or import; biting; sarcastic; cruel; harsh; rigorous; severe; as, a sharp rebuke. "That sharp look." "To that place the sharp Athenian law Can not pursue us." (Shak) "Be thy words severe, Sharp as merits but the sword forbear." (Dryden) 7. Of keen perception; quick to discern or distinguish; having nice discrimination; acute; penetrating; sagacious; clever; as, a sharp eye; sharp sight, hearing, or judgment. "Nothing makes men sharper . . . Than want." (Addison) "Many other things belong to the material world, wherein the sharpest philosophers have never ye arrived at clear and distinct ideas." (L. Watts) 8. Eager in pursuit; keen in quest; impatient for gratification; keen; as, a sharp appetite. 9. Fierce; ardent; fiery; violent; impetuous. "In sharp contest of battle." "A sharp assault already is begun." (Dryden) 10. Keenly or unduly attentive to one's own interest; close and exact in dealing; shrewd; as, a sharp dealer; a sharp customer. "The necessity of being so sharp and exacting." (Swift) 11. Composed of hard, angular grains; gritty; as, sharp sand. 12. Steep; precipitous; abrupt; as, a sharp ascent or descent; a sharp turn or curve. 13. Uttered in a whisper, or with the breath alone, without voice, as certain consonants, such as p, k, t, f; surd; nonvocal; aspirated. Sharp is often used in the formation of self-explaining compounds; as, sharp-cornered, sharp-edged, sharp-pointed, sharp-tasted, sharp-visaged, etc. Sharp practice, the getting of an advantage, or the attempt to do so, by a tricky expedient. To brace sharp, or To sharp up, to turn the yards to the most oblique position possible, that the ship may lie well up to the wind. Synonym: Keen, acute, piercing, penetrating, quick, sagacious, discerning, shrewd, witty, ingenious, sour, acid, tart, pungent, acrid, severe, poignant, biting, acrimonious, sarcastic, cutting, bitter, painful, afflictive, violent, harsh, fierce, ardent, fiery. Origin: OE. Sharp, scharp, scarp, AS. Scearp; akin to OS. Skarp, LG. Scharp, D. Scherp, G. Scharf, Dan. & Sw. Skarp, Icel. Skarpr. Cf. Escarp, Scrape, Scorpion. Source: Websters Dictionary (01 Mar 1998) |
| sharp spoon | An instrument with a small cup-shaped extremity having sharpened edges, used for scraping skin lesions. (05 Mar 2000) |
| abdominal pulse | The soft, compressible aortic pulse occurring in certain abdominal disorders. Synonym: pulsus abdominalis. (05 Mar 2000) |
| alternating pulse | Mechanical alternation, a pulse regular in time but with alternate beats stronger and weaker, often detectable only with the sphygmomanometer and usually indicating serious myocardial disease. Synonym: pulsus alternans. (05 Mar 2000) |
| amplitude of pulse | See: average pulse magnitude, peak magnitude. (05 Mar 2000) |
| anacrotic pulse | A pulse wave showing one or more notches or indentations on its rising limb that are sometimes detectable by palpation. Synonym: pulsus anadicrotus. (05 Mar 2000) |
| asynchronous pulse generator | A generator in which the rate of discharge is independent of the natural activity of the heart. Synonym: fixed rate pulse generator. (05 Mar 2000) |
| atrial synchronous pulse generator | A ventricular stimulating pulse whose rate of discharge is directly determined by the atrial rate. Synonym: atrial triggered pulse generator. (05 Mar 2000) |
| atrial triggered pulse generator | A ventricular stimulating pulse whose rate of discharge is directly determined by the atrial rate. Synonym: atrial triggered pulse generator. (05 Mar 2000) |
| average pulse magnitude | <physics> The amplitude of pulse averaged throughout its duration; identical with peak amplitude for a square wave or pulse without droop. (05 Mar 2000) |
| bigeminal pulse | A pulse in which the beats occur in pairs. Synonym: bigemina, coupled pulse, pulsus bigeminus. (05 Mar 2000) |
| bisferious pulse | An arterial pulse with peaks that may be palpable. Synonym: pulsus bisferiens. (05 Mar 2000) |
| bulbar pulse | A jugular pulse supposed to indicate tricuspid insufficiency. (05 Mar 2000) |
| cannonball pulse | <radiology> Corrigan's sign: increased pulse at wrist, aortic insufficiency, widened pulse pressure due to increased stroke volume, diastolic regurgitation (12 Dec 1998) |