| Schilder's disease | Term used to describe at least two separate disorders described by Schilder: 1) Diffuse sclerosis or encephalitis periaxialis diffusa; a nonfamilial disorder affecting primarily children and young adults and characterised by progressive dementia, visual disturbances, deafness, pseudobulbar palsy, and hemiplegia or quadriplegia. Most patients die within a few years of onset; pathologically, there is a large, asymmetrical area of myelin destruction, sometimes involving an entire cerebral hemisphere, and typically with extension across the corpus callosum. 2) The leukodystrophies. Synonym: encephalitis periaxialis diffusa, Flatau-Schilder disease. (05 Mar 2000) |
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| schilder syndrome | <radiology> Sudanophilic leukodystrophy, males (2:1), onset prepuberty, rapidly progressive demyelinating disease, weakness may lead to paralysis, apathy may lead to stupor, death usually in months, occipital and temporal most severely affected (12 Dec 1998) |
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| Flatau-Schilder disease | Term used to describe at least two separate disorders described by Schilder: 1) Diffuse sclerosis or encephalitis periaxialis diffusa; a nonfamilial disorder affecting primarily children and young adults and characterised by progressive dementia, visual disturbances, deafness, pseudobulbar palsy, and hemiplegia or quadriplegia. Most patients die within a few years of onset; pathologically, there is a large, asymmetrical area of myelin destruction, sometimes involving an entire cerebral hemisphere, and typically with extension across the corpus callosum. 2) The leukodystrophies. Synonym: encephalitis periaxialis diffusa, Flatau-Schilder disease. (05 Mar 2000) |