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saccharopine dehydrogenase (NAD+, L-glutamate-forming) [EC 1.5.1.9] an enzyme activity that catalyzes oxidative cleavage of saccharopine to form α-aminoadipate semialdehyde and glutamate, using NAD+ as an electron acceptor. The reaction is the second step in the major route of lysine degradation; the enzyme activity is part of the bifunctional enzyme α-aminoadipic semialdehyde synthase (q.v.). The enzyme activity is absent in hyperlysinemia and the variant saccharopinuria.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
saccharopine dehydrogenase (NADP+, L-lysine-forming) [EC 1.5.1.8] an enzyme activity that catalyzes the condensation of L-lysine and α-ketoglutarate to form saccharopine, using NADPH as an electron donor. The reaction is the initial step in the major route of lysine degradation; the enzyme activity is part of the bifunctional enzyme α-aminoadipic semialdehyde synthase (q.v.). The enzyme activity is absent in hyperlysinemia and substantially reduced in the variant saccharopinuria. Usually called lysine ketoglutarate reductase.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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