| rioprostil | <chemical> (11 alpha,13e)-1,11,16-trihydroxy-16-methylprost-13-en-9-one. A synthetic methylprostaglandin e1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against nsaid-induced gastric mucosal damage. The drug also prevents cyclosporin a-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies. Pharmacological action: anti-ulcer agents. Chemical name: Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)- (12 Dec 1998) |
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