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ribonucleinase <biochemistry, enzyme, molecular biology> Widely distributed type of enzyme that cleaves RNA. May act as endonucleases or exonucleases depending upon the type of enzyme. Generally recognise target by tertiary structure rather than sequence.
Ribonuclease E is involved in the formation of 5S ribosomal RNA from pre rRNA.
Ribonuclease F is stimulated by interferons and cleaves viral and host RNA and thus inhibits protein synthesis.
Ribonuclease H specifically cleaves an RNA base paired to a complementary DNA strand.
Ribonuclease P is an endonuclease that generate t RNA from their precursor transcripts.
Ribonuclease T is an endonuclease that removes the terminal AMP from the 3' CCA end of a nonaminoacylated tRNA. Ribonuclease T1 cleaves RNA specifically at guanosine residues. Ribonuclease TIII cleaves double stranded regions of RNA molecules.
Acronym: RNase
(23 Aug 1998)
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