| 영문 | interleukin | 한글 | 인터루킨 |
|---|---|---|---|
| 설명 | 면역계가 질병과 감염에 맞서 싸우도록 자극하는 단백질의 한 형태. 약칭은 IL이다. 백혈구(림프구)에서 만들어진다. 백혈구는 몸 안에 들어온 세균이나 다른 해로운 물질을 파괴하거나 제거한다. 여러 종류의 백혈구에서 인터루킨이 발견되었은데 물리적-화학적 성상이 확인된 것으로는 IL1, IL2, IL3, IL4, IL5, IL6 등이 있다. 이 인터루킨들은 함께 작용하여 백혈구가 질병에 대항하도록 연쇄적으로 반응한다. 예를 들어 상처 부위에 세균이 침입하면 큰포식세포라는 백혈구가 세균을 인식하고 인터루킨을 방출한다. 인터루킨은 백혈구의 일종인 T세포를 활성화한다. T세포는 세균을 파괴하며 인터루킨과 다른 유사한 화학물질을 방출하여 면역계의 여러 세포를 활성화시켜서 세균을 공격하게 한다. 당초에 인터루킨이라는 명칭은 백혈구간의 정보전달을 수행하는 물질이라는 의미로 붙여졌으나 현재 알려져 있는 10여종은 생산세포나 반응세포, 기능 등의 점에서 연관된다고는 할 수 없다. 인터루킨의 발견으로 몇 가지 형태의 암과 그 밖의 여러 질병의 치료가 보다 쉬워졌다. |
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| AChRs | Acetylcholine Receptors |
|---|---|
| RA | radioactive; ragocyte; ragweed antigen; rapidly adapting [receptors]; reactive arthritis; reciprocal... |
| IL-1 | Interleukin-1 |
| IL-8 | Interleukin-8 |
| HILDA | human interleukin in DA [cells] |
| AR | Alpha1-adrenergic receptors |
|---|---|
| alpha1-ARs | Alpha1-adrenergic receptors |
| beta 2AR | Beta 2-adrenergic receptors |
| CR1 | C3b-C4b receptors |
| CB1 | cannabinoid 1 receptors |
| receptors, interleukin | Cell surface proteins that bind interleukins and trigger intracellular changes influencing the behaviour of cells. (12 Dec 1998) |
|---|---|
| receptors, interleukin-1 | Specific molecular sites or structures on cells with which interleukin-1 reacts or to which it binds to modify the function of the cells. The il-1 receptor on T-lymphocytes and fibroblasts is composed of a single polypeptide chain that binds both il-1 alpha and il-1 beta. The molecular weight of this high-affinity receptor is believed to be 80 kD. (12 Dec 1998) |
| receptors, interleukin-2 | Receptors present on activated t- and B-cells as a complex consisting of a 55 kD peptide, which reacts with the anti-tac monoclonal antibody, and a 75 kD non-tac interleukin-2-binding peptide. The receptor is present in two forms, one with a very high affinity and the other with low affinity for il-2. The high-affinity form appears to mediate exclusively the growth-promoting response to il-2. The receptor is present in large numbers on resting HTLV-I leukaemia cells, but not on normal resting cells. (12 Dec 1998) |
| receptors, interleukin-3 | Phosphotyrosine-containing proteins, mw 140 kD. They form a stable complex with interleukin-3 with an apparent mass of 170 kD. They are found on a variety of cells and activate interleukin-3. (12 Dec 1998) |
| receptors, interleukin-4 | Receptors present on a wide variety of haematopoietic and non-haematopoietic cell types and various human tumours. Two forms of the receptor have been described, soluble and membrane-bound. Low affinity and high affinity receptors for il-4 have been reported. (12 Dec 1998) |
| receptors, interleukin-6 | <chemical> Receptors present on t cells, mitogen-activated B-cells, peripheral monocytes, and some macrophage- and B-cell-derived tumour cell types. The receptor is a strongly glycosylated protein of 80 kD and a length of 468 amino acids. Pharmacological action: growth inhibitors. (12 Dec 1998) |
| interleukin | <cytokine, protein> A variety of naturally occuring polypeptides that are members of the family of cytokines which affect functions of specific cell types and are found in small quantities. They are secreted regulatory proteins produced by lymphocytes, monocytes and various other cell types and are released by cells in response to antigenic and non-antigenic stimuli. Interleukins are of the larger class of T-cell products, lymphokines which are now more frequently considered as cytokines. The interleukins, of which there are 12 identified to date, modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Included among the cytokines are cachectin and lymphotoxin which are now known as tumour necrosis factor-alpha and tumour necrosis factor-beta, respectively. Interleukin-1 inhibitors are the first well-described proteins involved in the feedback regulation of interleukin activities. The origin and functions of the two most novel cytokines, interleukin-11 and interleukin-12 (also referred to as natural killer cell stimulatory factor), have only recently begun to be understood. (11 Mar 1998) |
|---|---|
| interleukin-1 | <cytokine> A soluble protein (17 kD: 152 amino acids) secreted by monocytes, macrophages or accessory cells involved in the activation of both T-lymphocytes and B lymphocytes and potentiates their response to antigens or mitogens. Its biological effects include the ability to replace macrophage requirements for T-cell activation, as well as affecting a wide range of other cell types. at least two IL-1 genes are active and alpha and beta forms of IL-1 are recognised. It is released early in an immune system response by monocytes and macrophages. It stimulates T-cell proliferation and protein synthesis. Another effect of IL-1 is that it causes fever. See: catabolin, endogenous pyrogen. Acronym: IL-1 (12 Dec 1998) |
| interleukin-10 | <cytokine> A factor produced by Th2 helper T-cells, some B-cells and LPS activated monocytes. It is a coregulator of mast cell growth. It is produced by T-cells and B-cells and shows extensive homology with the Epstein-Barr virus bcrfi gene. Chemical name: Cytokine formation-inhibiting factor (mouse clone F115 protein moiety reduced) Acronym: IL-10 (12 Dec 1998) |
| interleukin-11 | <cytokine> Pleiotropic cytokine originally isolated from primate bone marrow stromal cell line that has the ability to modulate antigen-specific antibody responses, potentiate megakaryocytes, and regulate bone marrow adipogenesis. Stimulates T-cell dependent B-cell maturation, megakaryopoiesis, various stages of myeloid differentiation. Receptor probably a tyrosine kinase. Acronym: IL-11 (12 Dec 1998) |
| interleukin-12 | <cytokine> A 75 kD heterodimeric cytokine composed of disulfide-bonded 40 kD and 35 kD subunits that was originally identified by its ability to induce cytotoxic effector cells in synergy with less than optimal concentrations of interleukin-2. It is released by macrophages in response to infection and promotes the activation of cell-mediated immunity. Specifically, IL-12 triggers the maturation of Thl CD4 cells, specific cytotoxic T-lymphocyte responses and an increase in the activity of NK cells and consequently, it is the initiator of cell-mediated immunity. It enhances the lytic activity of NK cells, induces interferon production, stimulates the proliferation of activated T-cells and NK cells. Is secreted by human B lymphoblastoid cells (NC 37). May play a role in controlling immunoglobulin isotype selection as it also inhibits IgE synthesis (even in the presence of anti-IFN monoclonal antibody) and as a growth factor for activated CD4+ and CD8+ T-cells independently of interleukin-2, and for CD56+ NK cells but not resting peripheral blood mononuclear cells or resting or activated tonsillar B-cells. It is likely that interleukin 12 has a major role in protective immunity against viruses and is under study as an immunotherapy in HIV infection. Formerly referred to as cytotoxic lymphocyte maturation factor. Acronym: IL-12 (12 Dec 1998) |
| interleukin-13 | <cytokine> A T-lymphocyte-derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-lymphocytes. It appears to play a role in regulating inflammatory and immune responses and has anti-inflammatory activity. Produced by activated T-cells, inhibits IL-6 production by monocytes and also the production of other pro inflammatory cytokines such as TNF, IL-1, IL-8. Stimulates B-cells. Gene is located in cluster of genes on human chromosome 5q that also has IL-4 gene. Acronym: IL-13 (12 Dec 1998) |
| interleukin-14 | Cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations. Acronym: IL-14 (12 Dec 1998) |
| interleukin-15 | Cytokine that stimulates the proliferation of T-lymphocytes and shares biological activities with il-2. Il-15 also can induce b-lymphocyte proliferation and differentiation. Acronym: IL-15 (12 Dec 1998) |
| interleukin-16 | Cytokine produced by activated T-lymphocytes that stimulates the migration of CD4-positive lymphocytes and monocytes. It has been reported to suppress HIV replication. (12 Dec 1998) |
| interleukin-1 converting enzyme | <biochemistry> Cytoplasmic cysteine protease that is uniquely responsible for cleaving proIL-1_ (31 or 33 kD) into mature IL-1_ (17.5 kD), the active cytokine is then released by a nonstandard mechanism (there is no signal sequence and it does not pass through the Golgi). The enzyme seems to be composed of two nonidentical subunits derived from a single proenzyme. The ICE gene has some homology with the ced 9 gene of C. Elegans, the product of which is involved in mediating cell death by apoptosis. (11 Mar 1998) |
| interleukin-2 | <cytokine> A hormone-like substance released by stimulated T lymphocytes, causes activation and differentiation of other T lymphocytes independently of antigen. A type of interleukin, a chemical messenger, a substance that can improve the body's response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system. It is secreted by Thl CD4 cells to stimulate CD8 cytotoxic T-1yrnphocytes. Interleukin 2 also increases the proliferation and maturation of the CD4 cells themselves. During HIV infection, Interleukin-2 production gradually declines. Use of interleukin 2 therapy is under study as a way to raise CD4 cell counts and restore immune function. Acronym: IL-2 (12 Dec 1998) |
| interleukin-3 | <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells. A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors. Synonym: multi-CSF Acronym: IL-3 (12 Dec 1998) |
| interleukin-4 | <cytokine> A soluble cytokine factor produced by activated T-lymphocytes that promotes antibody production by causing proliferation and differentiation of B-cells. Interleukin-4 induces the expression of class II major histocompatibility complex and fc receptors on B-cells. It also acts on T-lymphocytes, mast cell lines, and several other haematopoietic lineage cells including granulocyte, megakaryocyte, and erythroid precursors, as well as macrophages. Acronym: IL-4 (12 Dec 1998) |
| interleukin-5 | <cytokine> A factor promoting eosinophil differentiation and activation in haematopoiesis. It also triggers activated B-cells for a terminal differentiation into Ig-secreting cells. Acronym: IL-5 (12 Dec 1998) |
| interleukin-6 | <cytokine> A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate. An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow. Acronym: IL-6 (12 Dec 1998) |
Synonyms : Interleukin Receptor, Receptors, Interleukins, Interleukins Receptors, Receptor, Interleukin
Synonyms : IL1 Receptors, Interleukin 1 Receptor, IL 1 Receptors, Interleukin 1 Receptors, Receptor, Interleukin 1, Receptors, IL 1, Receptors, IL1, Receptors, Interleukin 1
Synonyms : Receptor Type I, Interleukin-1, CDw121a Antigens, Interleukin 1 Receptor Type I, Interleukin 1 Receptors Type I, Receptor Type I, Interleukin 1, Receptors, Interleukin 1 Type I
Synonyms : Interleukin-1 Receptor, Type 2, Interleukin-1 Receptors Type II, Interleukin 1 Receptor Type II, Interleukin 1 Receptor, Type 2, Interleukin 1 Receptors Type II, Receptors, Interleukin 1 Type II
Synonyms : IL-10 Receptor, Interleukin-10 Receptor, Receptor, Interleukin-10, IL 10 Receptor, IL-10 Receptors, Interleukin 10 Receptor, Interleukin 10 Receptors, Receptor, IL-10, Receptor, Interleukin 10, Receptors, IL 10, Receptors, Interleukin 10
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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