| pyroglobulins | Atypical gamma immunoglobulins characterised by their irreversible heat denaturation at 56-degrees c. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of pyroglobulins in the serum is the cause of pyroglobulinaemia. They are frequently present in multiple myeloma and the pyroglobulin precipitate binds complement, reacts with rheumatoid factor, produces passive cutaneous anaphylaxis, generalised passive anaphylaxis and passive arthus-type phenomena. (12 Dec 1998) |
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