| proteoglycan | <protein> A high molecular weight complex of protein and polysaccharide, characteristic of structural tissues of vertebrates, such as bone and cartilage, but also present on cell surfaces. Important in determining viscoelastic properties of joints and other structures subject to mechanical deformation. Glycosaminoglycans (GAGs), the polysaccharide units in proteoglycans, are polymers of acidic disaccharides containing derivatives of the amino sugars glucosamine or galactosamine. (18 Nov 1997) |
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| proteoglycan I | A small proteoglycan, 150-240 kD, of the extracellular matrix. The core protein has a mass of _42 kD and is very similar to the core protein of decorin and fibromodulin. All three have highly conserved sequences containing 10 internal homologous repeats of _ 25 amino acids with leucine rich motifs. Biglycan has two glycosaminoglycan chains, either chondroitin sulphate or dermatan sulphate and N linked oligosaccharides. (18 Nov 1997) |
| proteoglycanase | <enzyme> Metal-dependent; acts at neutral pH; degrades the protein core without acting on carbohydrate side chains Registry number: EC 3.4.- (26 Jun 1999) |
| proteoglycans | Glycoproteins which have a very high polysaccharide content. (12 Dec 1998) |
| heparan sulfate proteoglycan | Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (12 Dec 1998) |
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