| protamine | Highly basic (arginine rich) protein that replaces histone in sperm heads, enabling DNA to pack in an extremely compacted form, for example clupein, iridin (4K). See: transition proteins. (18 Nov 1997) |
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| protamine kinase | <enzyme> An aspect of protein kinase (ec 2.7.1.37) in which serine residues in protamines and histones are phosphorylated in the presence of ATP. Chemical name: ATP:protamine O-phosphotransferase Registry number: EC 2.7.1.70 (12 Dec 1998) |
| protamine sulfate | A purified mixture of simple protein principles from the sperm or testes of suitable species of fish; it is a heparin antagonist used in certain haemorrhagic states associated with increased amounts of heparin-like substances in the circulation and for the treatment of heparin overdosage. (05 Mar 2000) |
| protamine zinc insulin | Insulin modified by the addition of protamine and zinc chloride; it contains 40 or 80 units per ml. (05 Mar 2000) |
| protamines | <chemical> A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralise the anticoagulant action of heparin in the treatment of heparin overdose. Pharmacological action: heparin antagonists. (12 Dec 1998) |
| insulin, protamine zinc | <chemical> A long-acting insulin with an approximate time of onset of 7 hours and duration of action 36 hours, consisting of bovine or pork insulin reacted with zinc chloride and protamine to form a protein complex from which insulin is slowly released. Pharmacological action: hypoglycaemic agents. Chemical name: Insulin protamine zinc (12 Dec 1998) |
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