| maturation-promoting factor | <enzyme> A protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by cyclins, maturation-promoting factor directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of maturation-promoting factor is protein p34cdc2. Acronym: MPF (12 Dec 1998) |
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| M phase promoting factor | Protein whose levels rise rapidly just before and fall away just after, mitosis. Thought to be a trigger for mitosis. (18 Nov 1997) |
| leukocytosis-promoting factor | A substance obtained by Menkin from inflammatory exudates; it stimulates leukocytosis. (05 Mar 2000) |