| prolyl | The acyl radical of proline. Prolyl dipeptidase, an enzyme cleaving l-prolyl-amino acid bonds in dipeptides containing N-terminal prolyl residues. Synonym: iminodipeptidase, prolinase, prolylglycine dipeptidase. Prolyl hydroxylase, an enzyme that catalyses the hydroxylation of certain prolyl residues in collagen precursors using molecular oxygen, ferrous ion, ascorbic acid, and alpha-keotglutarate; a vitamin C deficiency directly affects the activity of this enzyme; one form of this enzyme (prolyl 4-hydroxylase) synthesises 4-hydroxyprolyl residues while another produces 3-hydroxyprolyl residues. (05 Mar 2000) |
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| prolyl aminopeptidase | <enzyme> Pepi gene product isolated from lactobacillus delbrueckii Registry number: EC 3.4.11.5 Synonym: proline aminopeptidase, cytosol aminopeptidase v, proline-imino-peptidase, proline iminopeptidase, pro-x aminopeptidase, pepi gene product, pip gene product, xanthomonas (26 Jun 1999) |
| prolyl hydroxylase | Specific proline residues on the amino side of a glycine residue in collagen become hydroxylated at C4, before the polypeptides become helical, by the activity of prolyl hydroxylase. This enzyme has a ferrous ion at the active site and a reducing agent such as ascorbate is necessary to maintain the iron in the ferrous state. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls (see HRGP). (18 Nov 1997) |
| prolyl oligopeptidase | <enzyme> Cleaves dipeptides from n-terminal end of peptide chain if penultimate residue is proline; before 1992 prolyl endopeptidase (thiol-dependent) was EC 3.4.22.18 Registry number: EC 3.4.21.26 Synonym: post-proline cleaving enzyme, proline specific endopeptidase, post-proline endopeptidase, prolyl endopeptidase, proline endopeptidase, prolyl endopeptidase I, prolyl endopeptidase (thiol-dependent) (26 Jun 1999) |
| prolyl T RNA synthetase | <enzyme> Minor descriptor (75-84); on-line and index medicus search amino acyl t RNA synthetases (75-84) Registry number: EC 6.1.1.15 Synonym: l-proline-trna-pro ligase (AMP-forming) (26 Jun 1999) |
| prolylglycine dipeptidase | prolyl dipeptidase |
| peptidyl prolyl cis trans isomerase | See: PPIase and immunophilin. (18 Nov 1997) |
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| succinylalanyl-alanyl-prolyl-phenylalanyl-7-amino-4-methylcoumarin hydrolase | <enzyme> Enzyme may be involved in attainment of transformed state Registry number: EC 3.4.24.- Synonym: suc-ala-ala-pro-phe-amc hydrolase, saapp-amc-hydrolase (26 Jun 1999) |
| (3-(arginyl)amino-4-(4-nitrophenyl)butyryl)-leucyl-prolyl-threonine | Pharmacological action: neurotransmitters Synonym: 2-afb(p-no2)-proctolin, (afb(p-no2)(2))-proctolin (26 Jun 1999) |