| prolactin-inhibiting factor | A substance of hypothalamic origin capable of inhibiting the synthesis and release of prolactin. Synonym: prolactin-inhibiting factor, prolactin-inhibiting hormone. Origin: prolactin + G. Stasis, standing still, + -in (05 Mar 2000) |
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| prolactin-releasing factor | A substance of hypothalamic origin that stimulates the release of prolactin. Synonym: prolactin-releasing factor, prolactin-releasing hormone. Origin: prolactin + L. Libero, to free, + -in (05 Mar 2000) |
| migration-inhibitory factor | <growth factor> A soluble, nondialysable factor that is produced by sensitised lymphocytes following exposure to a specific antigen. It inhibits macrophage migration and causes adherence. It was originally defined on the basis of inhibition of emigration of mononuclear cells from capillary (haematocrit) tubes, more recently a 13 kD protein with migration inhibitory activity has been isolated. Acronym: MIF Synonym: inhibition factor. (22 Sep 2002) |
| migration-inhibitory factor test | A test which measures the presence of migration-inhibitory factor. Usually peritoneal macrophages are placed in a capillary tube in the presence or absence of supernatants from activated T-cells. If MIF is present, the migration of monocyte/macrophages is reduced. Synonym: macrophage migration inhibition test, migration inhibition test. (05 Mar 2000) |
| Leukaemia inhibitory factor | <growth factor> Polypeptide growth factor or cytokine with wide range of activities. Regulates growth and differentiation of primordial germ cells and embryonic stem cells but has effects on peripheral neurons, osteoblasts, adipocytes and various cells of the myeloid lineage. Given to adult animals induces weight loss, behavioural disorders and bone abnormalities. Many of the effects of LIF in vitro can be mimicked by IL-6, oncostatin M and ciliary neurotrophic factor, all of which interact indirectly with gp130, a shared tranducer subunit. (18 Nov 1997) |
| receptors, prolactin | Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor. (12 Dec 1998) |
| chorionic growth hormone-prolactin | human placental lactogen |
| prolactin | <protein> Pituitary lactogenic hormone (23 kD) Synthesised on endoplasmic reticulum bound ribosomes as preprolactin that has an N terminal signal peptide that is cleaved from the mature form. The conversion of preprolactin to prolactin has been much used as an assay for membrane insertion. (18 Nov 1997) |
| prolactin cell | An acidophilic cell of the adenohypophysis that produces prolactin. Synonym: prolactin cell. (05 Mar 2000) |
| prolactin-inhibiting hormone | A substance of hypothalamic origin capable of inhibiting the synthesis and release of prolactin. Synonym: prolactin-inhibiting factor, prolactin-inhibiting hormone. Origin: prolactin + G. Stasis, standing still, + -in (05 Mar 2000) |
| prolactin-producing adenoma | <tumour> A pituitary adenoma composed of prolactin-producing cells; it gives rise to symptoms of nonpuerperal amenorrhoea and galactorrhoea (Forbes-Albright syndrome) in women and to impotence in men. Synonym: prolactinoma. (05 Mar 2000) |
| prolactin protease | <enzyme> From pituitary lysosomes of lactating rats Registry number: EC 3.4.99.- (26 Jun 1999) |
| prolactin release-inhibiting hormone | <chemical> A polypeptide hormone produced in the hypothalamus that inhibits the release of prolactin. Chemical name: Prolactin release-inhibiting factor (12 Dec 1998) |
| prolactin-releasing hormone | A polypeptide hormone that originates in the hypothalamus and stimulates the secretion of prolactin in the pituitary gland. (12 Dec 1998) |
| prolactin unit | The specific lactogenic activity contained in 0.1 mg of the standard preparation of the lactogenic substance of the anterior pituitary gland. (05 Mar 2000) |