| pristinamycin IIA synthase | <enzyme> A heterodimer of snaa and snab proteins (snaa and snab gene products, respectively); catalyses the oxidation of piib to piia with fmnh2 and o2 as cofactors; from streptomyces pristinaespiralis. Registry number: EC 1.3.99.- Synonym: pii(a) synthase, piia synthase (26 Jun 1999) |
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| pristinamycin I synthetase | <enzyme> Involved in pristinamycin 1 biosynthesis; includes at least 4 peptide synthetases involved in the activation and condensation of the pristinamycin I precursors - snba, snbc, snbd and snbe (pi synthetase 1, 2, 3, 4 respectively Registry number: EC 6.3.2.- Synonym: pi synthetase (26 Jun 1999) |
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| factor IIa | <enzyme> Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. (18 Nov 1997) |
| abequose synthase | <enzyme> Converts cdp-4-keto-3,6-dideoxy-d-glucose to cdp-3,6-dideoxy-d-galactose (cdp-abequose); requires NADPH, analogous to udp-glucose-4-epimerase Registry number: EC 5.1.3.- Synonym: rfbj gene product (26 Jun 1999) |
| acetoacetyl-acyl carrier protein synthase | <enzyme> E coli enzyme, that catalyses condensation of malonyl-acyl carrier protein plus acetyl-acyl carrier protein; not inhibited by cerulenin Registry number: EC 2.3.1.- Synonym: acetoacetyl-acp synthase (26 Jun 1999) |
| acetolactate synthase | <enzyme> A flavoprotein that catalyses the formation of acetolactate from 2 moles of pyruvate in the biosynthesis of valine and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of isoleucine. Chemical name: Acetolactate pyruvate-lyase (carboxylating) Registry number: EC 4.1.3.18 (12 Dec 1998) |
| acridone synthase | <enzyme> Catalyses the condensation of n-methylanthraniloyl-CoA and 3 malonyl-CoA to produce 1,3-dihydroxy-n-methylacridone Registry number: EC 2.3.1.- (26 Jun 1999) |
| acyl-malonyl-ACP synthase | <enzyme> An enzyme condensing malonyl-ACP and acyl-cys-protein to 3-oxoacyl-ACP + cys-protein + CO2, and similar reactions, as steps in fatty acid synthesis; cys-protein is also a part of the fatty acid synthase complex. Synonym: acyl-malonyl-ACP synthase, beta-ketoacyl-ACP synthase. (05 Mar 2000) |
| adenylosuccinate synthase | <enzyme> A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyses the synthesis of adenylosuccinate from GTP, imp, and aspartate with the formation of orthophosphate and GDP. Chemical name: IMP:L-aspartate ligase (GDP-forming) Registry number: EC 6.3.4.4 (12 Dec 1998) |
| adenylylosuccinate synthase | <enzyme> A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyses the synthesis of adenylosuccinate from GTP, imp, and aspartate with the formation of orthophosphate and GDP. Chemical name: IMP:L-aspartate ligase (GDP-forming) Registry number: EC 6.3.4.4 (12 Dec 1998) |
| agropine synthase | <enzyme> Final enzyme in the three enzyme pathway for agropine synthesis; cyclises deoxymannityl-glutamine to the lactone, agropine Registry number: EC 4.2.1.- Synonym: ags gene product (26 Jun 1999) |
| alkylglycerone-phosphate synthase | <enzyme> Replaces the acyl moiety of acyldhap with a long chain fatty alcohol; intact alcohol including the oxygen atom is incorporated into alkyl-dhap Registry number: EC 2.5.1.26 Synonym: adhps, alkyl-dihydroxyacetone phosphate synthase, alkyl-dhap synthase, alkyldihydroxyacetone phosphate synthetase, acylglycerone-3-phosphate-long chain-alcohol o-3-phospho-2-oxopropanyl transferase, alkyldihydroxyacetonephosphate synthase (26 Jun 1999) |
| aminoadipic d-saemialdehyde synthase | <enzyme> A bifunctional enzyme used in lysine degradation; it has a lysine:alpha-ketoglutarate reductase activity as well as a saccharopine dehydrogenase activity. A deficiency of this enzyme results in familial hyperlysinaemia. (05 Mar 2000) |
| aminoadipic saemialdehyde synthase | <enzyme> Bifunctional enzyme with both lysine-ketoglutarate reductase (EC 1.5.1.8) and saccharopine dehydrogenase (EC 1.5.1.9) activities Registry number: EC 1.5.1.- Synonym: aasa synthase (26 Jun 1999) |
| aminodeoxychorismate synthase | <enzyme> From E coli; probably catalyses the conversion of chorismate to 4-amino-4-deoxychorismate; see also paba protein Registry number: EC 2.6.1.- Synonym: pabb gene product, adc synthase (26 Jun 1999) |
| amylopectin synthase | <enzyme> From eimeria tenella; catalyses udpglucose alpha 1,4-glucan alpha-4-glucosyltransferase forming amylopectin, similar to glycogen synthase in eukaryotes Registry number: EC 2.4.1.- (26 Jun 1999) |