| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
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| cold pressor test | A cardiocirculatory challenge conventionally performed by immersing one hand in ice cold water for two or more minutes (as tolerated) to acutely raise the blood pressure, thus imposing resistance to ejection of blood from the left ventricle into the systemic arterial system and consequently acutely increased afterload (afterload = increased left ventricular wall stress). Synonym: Hines-Brown test. (05 Mar 2000) |
| pressor | <physiology> Causing, or giving rise to, pressure or to an increase of pressure; as, pressor nerve fibres, stimulation of which excites the vasomotor center, thus causing a stronger contraction of the arteries and consequently an increase of the arterial blood pressure. Compare: depressor. (05 Mar 1998) |
| pressor amine | One of several products of intestinal putrefaction believed to cause functional hypertension when absorbed, any alkaline substance that raises blood pressure. Synonym: pressor amine, pressor substance. (05 Mar 2000) |
| pressor base | One of several products of intestinal putrefaction believed to cause functional hypertension when absorbed, any alkaline substance that raises blood pressure. Synonym: pressor amine, pressor substance. (05 Mar 2000) |
| pressor fibres | Sensory nerve fibre's whose stimulation causes vasoconstriction and rise of blood pressure. (05 Mar 2000) |
| pressor nerve | An afferent nerve, stimulation of which excites a reflex vasoconstriction, thereby raising the blood pressure. (05 Mar 2000) |
| pressor substance | One of several products of intestinal putrefaction believed to cause functional hypertension when absorbed, any alkaline substance that raises blood pressure. Synonym: pressor amine, pressor substance. (05 Mar 2000) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| activity, drug | A measure of the physiological response a drug produces in the body. A less active drug produces less response (and visa versa). (12 Dec 1998) |
| addictive drug | Any drug that creates a certain degree of euphoria and has a strong potential for addiction. (05 Mar 2000) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |
| maintenance drug therapy | In chemotherapy, systematic dosage at a level that maintains protection against exacerbation. (05 Mar 2000) |