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pp60 <molecular biology> The phosphoprotein (60 kD) encoded by the src oncogene. A tyrosine kinase.
(18 Nov 1997)
CancerWEB ¿µ¿µ ÀÇÇлçÀü À¯»ç °Ë»ö °á°ú : 2 ÆäÀÌÁö: 1
proto-oncogene protein pp60(c-src) <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase.
Registry number: EC 2.7.1.-
(12 Dec 1998)
oncogene protein pp60(v-src) <chemical> Tyrosine-specific protein kinase encoded by the v-src oncogene of rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its n-terminal glycine.
Chemical name: Kinase (phosphorylating), protein pp60src
(12 Dec 1998)
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