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podocyte <pathology> Cells of the visceral epithelium that closely invest the network of glomerular capillaries in the kidney.
most of the cell body is not in contact with the basal lamina, but is separated from it by trabeculae that branch to give rise to club shaped protrusions, known as pedicels, interdigitating with similar processes on adjacent cells.
The complex interdigitation of these cells produces thin filtration slits that seem to be bridged by a layer of material (of unknown composition), that acts as a filter for large macromolecules.
(18 Nov 1997)
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  • Podocytes - »õâ Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.
    Synonyms : Epithelial Cells, Glomerular Visceral, Glomerular Visceral Epithelial Cells, Podocyte
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podocyte Podocytes are cells of the visceral epithelium in the kidneys and form a crucial component of the glomerular filtration barrier by covering the exterior basement surface of the glomerular capillary and maintaining a massive filtration surface. ...
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