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phosphorylase kinase [EC 2.7.1.38] an enzyme of the transferase class that catalyzes the phosphorylation of (inactive) glycogen phosphorylase b to form (active) glycogen phosphorylase a, a step in the cascade of reactions regulating glycogenolysis. The enzyme is itself activated via phosphorylation by cyclic-AMP–dependent protein kinase, and one of its four subunits is identical to calmodulin. Deficiency of the enzyme in liver, an X-linked trait, causes phosphorylase b kinase deficiency.
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