| PDK1 | 3'-phosphoinositide-dependent kinase-1 |
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| PDK1 | 3'-phosphoinositide-dependent protein kinase 1 |
| PI | Phosphoinositide |
| PPI | Phosphoinositide |
| PI3K | Phosphoinositide 3 kinase |
| phosphoinositide | <biochemistry> A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers. Synonym: phosphoinositide. (20 Sep 2002) |
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| 3-phosphoinositide-dependent protein kinase | <enzyme> Enzyme from rabbit skeletal muscle phosphorylates protein kinase b at thr308; activated by phosphatidylinositol 3,4,5-trisphosphate or phosphatidylinositol 3,4-bisphosphate Registry number: EC 2.7.10.- Synonym: pdk1 enzyme, ptdins(3,4,5)p3-dependent protein kinase-1 (26 Jun 1999) |
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| phosphoinositide |
A phosphorylated derivative of the glycerolipid phosphatidylinositol. As three positions of the inositol ring can be phosphorylated independently of each other, there are seven possible phosphoinositides.
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