| phosphodiesterase | <enzyme> An enzyme that cleaves phosphodiesters to give a phosphomonoester and a free hydroxyl group. Examples include RNase, DNase, phospholipases C and D and the enzymes that convert cyclic nucleotides to the monoester forms. In casual usage the cAMP phosphodiesterase is usually meant. (18 Nov 1997) |
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| phosphodiesterase inhibitors | Compounds which inhibit or antagonise the biosynthesis or actions of phosphodiesterases. (12 Dec 1998) |
| phosphodiesterase-phosphomonoesterase | <enzyme> From fusarium moniliforme; hydrolyzes both phosphodiesters and phosphomonoesters Registry number: EC 3.1.- Synonym: pdmase (26 Jun 1999) |
| phosphodiesterases | Enzymes (EC sub-subclass 3.1.4) cleaving phosphodiester bonds, such as those in cAMP or between nucleotides in nucleic acids, liberating smaller poly-or oligonucleotide units or mononucleotides but not inorganic phosphate. Synonym: phosphodiester hydrolases. (05 Mar 2000) |
| adenosine 3',5'-cyclic phosphate phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of adenosine 3',5'-cyclic phosphate forming 5'-AMP. A crucial step in the regulation of cellular adenosine 3',5'-cyclic phosphate levels. Inhibited by caffeine. Synonym: cAMP phosphodiesterase. (05 Mar 2000) |
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| alkylglycerophosphoethanolamine phosphodiesterase | <enzyme> From microsomal preparations of rabbit kidney medulla; hydrolyzes choline moiety from lyso-paf to form 1-alkyl-2-lysoglycerophosphate in rat brain and other tissue; only lysoglycerophospholipids with ether linkages at the sn-1 position serve as substrates; acyl analogs are not utilised; requires magnesium Registry number: EC 3.1.4.39 Synonym: lysophospholipase d (26 Jun 1999) |
| calcium-calmodulin-dependent phosphodiesterase | <enzyme> Hydrolyzes both cgmp and camp; induced during mitogenesis Registry number: EC 3.1.4.- Synonym: ca-cam-phosphodiesterase, calmodulin-dependent cgmp phosphodiesterase (26 Jun 1999) |
| cAMP phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of adenosine 3',5'-cyclic phosphate forming 5'-AMP. A crucial step in the regulation of cellular adenosine 3',5'-cyclic phosphate levels. Inhibited by caffeine. Synonym: cAMP phosphodiesterase. (05 Mar 2000) |
| gamma subunit, cGMP phosphodiesterase | <enzyme> Isolated from canine retinal rod photoreceptor cells; genbank u49359 Registry number: EC 3.1.14.- Synonym: pde-gamma, pdegamma, cgmp-pde gamma subunit (26 Jun 1999) |
| PDE4D3 phosphodiesterase | <enzyme> One of three variants encoded by pde4d gene; this form is expressed in rat thyroid cells Registry number: EC 3.1.4.- (26 Jun 1999) |
| glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase | <enzyme> Removes the glucose-1-phosphate from glc-alpha-1-p-6-mannose residues in glycoproteins as a unit; pH optimum 7.5 Registry number: EC 3.1.4.51 Synonym: ag1p phosphodiesterase, alpha-glucose-1-phosphate phosphodiesterase (26 Jun 1999) |
| glycerophosphodiester phosphodiesterase | <enzyme> E coli enzyme; acts on variety of substrates to give glycerol-3-phosphate plus an alcohol, such as ethanolamine, choline, glycerol or glycerophosphoglycerol Registry number: EC 3.1.4.46 Synonym: gpde-phosphodiesterase, glycerophosphosphoryl diester phosphodiesterase (26 Jun 1999) |
| monoacylglycerophosphorylglycerophosphorylglycerol phosphodiesterase | <enzyme> Hydrolyzes agpgpg to lysophosphatidylglycerol and alpha-glycerophosphate Registry number: EC 3.1.4.- Synonym: agpgpgase (26 Jun 1999) |
| sphingomyelin phosphodiesterase | <enzyme> An enzyme that catalyses the hydrolysis of sphingomyelin to ceramide (n-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to niemann-pick disease. Chemical name: Sphingomyelin cholinephosphohydrolase Registry number: EC 3.1.4.12 (12 Dec 1998) |
| dolichyl-phosphate-mannose phosphodiesterase | <enzyme> Chicken liver microsome enzyme releases mannose plus dolichyl phosphate Registry number: EC 3.1.4.49 Synonym: dol-p-man phosphodiesterase, mannosylphosphodolichol phosphodiesterase (26 Jun 1999) |
| inositol cyclic 1,2-phosphate 1-phosphodiesterase | <enzyme> Converts inositol 1:2-cyclic phosphate to inositol 2-phosphate; do not confuse with inositol 1,2 cyclic-phosphate 2-phosphohydrolase see annexin III Registry number: EC 3.1.4.- Synonym: cins(1,2)p hydrolase II (26 Jun 1999) |
| oligophosphoglyceroyl-ATP 3'-phosphodiesterase | <enzyme> Located in mitochondrial fraction of rat liver; selectively hydrolyzes the oligo cpd to monomeric units of 3-phosphoglyceroyl-gamma-triphospho-5'-adenosine Registry number: EC 3.1.4.- Synonym: opg-ATP-phosphodiesterase (26 Jun 1999) |
| thiazole-4-carboxamide-adenine dinucleotide phosphodiesterase | <enzyme> Hydrolyzes thiazole-4-carboxamide adenine dinucleotide, releasing AMP Registry number: EC 3.1.4.- Synonym: tad-phosphodiesterase (26 Jun 1999) |
| 2',3'-cyclic nucleotide 2'-phosphodiesterase | <enzyme> Catalyses the hydrolysis of the 2'-phosphodiesterase bond to yield nucleoside 3'phosphate Registry number: EC 3.1.4.16 Synonym: 2',3'-cyclic nucleotide 2'-phosphohydrolase (26 Jun 1999) |