| ECG | Electro-Cardio-Graphy(-Gram); ½ÉÀüµµ = EKG 1. Conducting System Structu... |
|---|---|
| AER | abduction/external rotation; acoustic evoked response; acute exertional rhabdomyolysis; agranular en... |
| SR | sarcoplasmic reticulum; saturation recovery; scanning radiometer; screen; secretion rate; sedimentat... |
| ERA | electrical response activity; electroencephalic response audiometry; Electroshock Research Associati... |
| RR | radiation reaction; radiation response; rate ratio; rational recovery [group]; recovery room; relati... |
| PI | 1-phosphatidylinositol |
|---|---|
| Pl | 1-phosphatidylinositol |
| PtdIns | 1-phosphatidylinositol |
| PI 3-kinase | 1-phosphatidylinositol 3-kinase |
| PtdIns 3-kinase | 1-phosphatidylinositol 3-kinase |
| phosphatidylinositol | <biochemistry> A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers. Synonym: phosphoinositide. (20 Sep 2002) |
|---|---|
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | <enzyme> Hydrolyzes the 5-position phosphate of ptdins(3,4,5)p3 forming phosphatidylinositol-3,4-bisphosphate; an isoenzyme forms a complex with the p85/p110 form of pi 3-kinase Registry number: EC 3.1.3.- Synonym: ptdins(3,4,5)p3 5-phosphatase, pi(3,4,5)p3 5-pase (26 Jun 1999) |
| phosphatidylinositol-3-phosphatase | <enzyme> Hydrolyzes phosphatidylinositol 3-phosphate in nih 3t3 cells; specific as it has little or no activity on the monoester phosphates of ptdins(4)p, ptdins(4,5)p2, or inositol 1,3-bisphosphate; does not require added metal ions for activity and is maximally active in the presence of edta; inhibited by ca(2+), mg(2+),zn(2+), and the phosphatase inhibitor vo(3-)4 Registry number: EC 3.1.3.64 Synonym: phosphatidylinositol 3-phosphatase (26 Jun 1999) |
| phosphatidylinositol 4,5-bisphosphate | <biochemistry> This is a molecule of phosphatidylinositol with two additional sites of phosphorylation. It is an important constituent of cell membrane phospholipids as well as a precursor of the second messengers, diacylglycerol and inositol 1,4,5-trisphosphate. Acronym: PIP2 (20 Sep 2002) |
| phosphatidylinositol 4,5-bisphosphate kinase | <enzyme> Membrane-associated enzyme Registry number: EC 2.7.1.- Synonym: ptdins 4,5-p2 kinase, phosphatidylinositol 4,5-bisphosphate kinase, ptdins(4,5)p2 3oh-kinase (26 Jun 1999) |
| phosphatidylinositol 4,5-diphosphate | <biochemistry> A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase c, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (12 Dec 1998) |
| phosphatidylinositol 4-phosphate | <biochemistry> The intermediate in the biosynthesis of phosphatidylinositol 4,5-bisphosphate from phosphatidylinositol. (20 Sep 2002) |
| phosphatidylinositol 4-phosphate phosphatase | <enzyme> From human erythrocyte membranes Registry number: EC 3.1.3.- Synonym: ptdins-4p-phosphatase, phosphatidylinositol-4-phosphate monoesterase, ptdins4p monoesterase (26 Jun 1999) |
| phosphatidylinositol-ceramide phosphoinositol transferase | <enzyme> Involved in biosynthesis of inositol-containing sphingolipids; isolated from saccharomyces cerevisiae Registry number: EC 2.4.1.- Synonym: ipc synthase (26 Jun 1999) |
| phosphatidylinositol phosphates | <biochemistry> Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group. (12 Dec 1998) |
| phosphatidylinositol synthase | <enzyme> An enzyme that catalyses the reaction of CDP-diacylglycerol with inositol to form CMP and phosphatidylinositol; found in the endoplasmic reticulum. (20 Sep 2002) |
| N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase | <enzyme> Involved in formation of glycosylphosphatidyl inositol membrane anchors in trypanosoma brucei; forms glucosaminyl-phosphatidylinositol Registry number: EC 3.5.1.- Synonym: glcnac-pi de-n-acetylase, pig-l protein, phosphatidylinositol glycan class l protein, n-acetylglucosaminyl-phosphatidylinositol deacetylase (26 Jun 1999) |
| 1-phosphatidylinositol 3-kinase | <enzyme> An enzyme that catalyses the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, v(d)j recombination and cell cyle checkpoints.37. Chemical name: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase Registry number: EC 2.7.1.137 (12 Dec 1998) |
| 1-phosphatidylinositol 4-kinase | <enzyme> An enzyme that catalyses the conversion of phosphatidylinositol to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Chemical name: ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate Registry number: EC 2.7.1.67 (12 Dec 1998) |
| anamnestic response | <immunology> Archaic term now replaced by such terms as secondary immune response, immune memory. (18 Nov 1997) |
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