| phorbol | The parent alcohol of the cocarcinogens, which are 12,13(9,9a) diesters of phorbol found in croton oil; the hydrocarbon skeleton is a cyclopropa-benzazulene; phorbol esters mimic 1,2-diacylglycerol as activators of protein kinase C. (05 Mar 2000) |
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| phorbol 12,13-dibutyrate | <chemical> 1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro 4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl) 1,1,6,8-tetramethyl-5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one butanoic acid diester. A phorbol ester found in croton oil which, in addition to being a potent skin tumour promotor, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase c). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems. Pharmacological action: carcinogens. Chemical name: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))- (12 Dec 1998) |
| phorbol ester | <chemical> Polycyclic compound isolated from croton oil in which two hydroxyl groups on neighbouring carbon atoms are esterified to fatty acids. The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co carcinogens or tumour promotors, they are diacyl glycerol analogues and activate protein kinase C irreversibly. (31 Dec 1997) |
| phorbol esters | <chemical> Tumour-promoting compounds obtained from croton oil (croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase c. Pharmacological action: carcinogens. (12 Dec 1998) |
| phorbols | The parent alcohol of the tumour promoting compounds from croton oil (croton tiglium). (12 Dec 1998) |