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phenoxybenzamine <chemical> N-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl) benzenemethanamine. An alpha-adrenergic anatagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Pharmacological action: adrenergic alpha-antagonists, antihypertensive agents, sympatholytics, vasodilator agents.
Chemical name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
(12 Dec 1998)
phenoxybenzamine hydrochloride (2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl benzylamine hydrochloride;a potent adrenergic (alpha-receptor) blocking agent of the beta-haloalkylamines; selectively blocks the excitatory response of smooth muscle and exocrine glands to epinephrine; used in the treatment of peripheral vascular diseases and in pheochromocytoma.
(05 Mar 2000)
phenoxybenzoate dioxygenase <enzyme> Catalyses conversion of 3- or 4-phenoxybenzoate to phenol and protocatechuate via a putative hemiacetal intermediate.
Registry number: EC 1.14.14.-
Synonym: 4-carboxydiphenyl ether dioxygenase, pob dioxygenase, pobb gene product
(26 Jun 1999)
phenoxymethylpenicillin <chemical> (2s-(2 alpha,5 alpha,6 beta)-3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylic acid. A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Pharmacological action: penicillins.
Chemical name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))-
(12 Dec 1998)
phenoxymethylpenicillin amidohydrolase <enzyme> Isolated from penicillium chrysogenes; hydrolyses phenoxymethylpenicillin to 6-aminopenicillanic acid (6-apa)
Registry number: EC 3.5.1.-
Synonym: pmp amidase
(26 Jun 1999)
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