| peptide chain initiation | The process whereby the formation of a peptide chain is started. This process requires (1) the 30s subunit, (2) the mRNA coding for the polypeptide to be made, (3) met-trnai, (4) initiation factors, and (5) GTP. (12 Dec 1998) |
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| peptide initiation factors | Protein factors uniquely required during the initiation phase of protein synthesis. (12 Dec 1998) |
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| peptide chain elongation | The process whereby an amino acid is joined through a substituted amide linkage to a chain of peptides. (12 Dec 1998) |
| peptide chain termination | The process whereby the last amino acid is added to a polypeptide. This termination is signaled by one of three termination triplets in the mRNA, immediately following the last amino acid codon. (12 Dec 1998) |
| chain, orthodontic chain | <dentistry> A stretchable plastic chain used to hold archwires into brackets and to moke teeth. (08 Jan 1998) |
| initiation | 1. The first stage of tumour induction by a carcinogen; subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumour upon subsequent exposure to a promoting agent (promotion). 2. Starting point of replication or translation in macromolecule biosynthesis. 3. Start of chemical or enzymatic reaction. (05 Mar 2000) |
| initiation codon | The codon 5' AUG in mRNA, at which polypeptide synthesis is started. It is recognised by formylmethionyl tRNA in bacteria and by methionyl tRNA in eukaryotes. (18 Nov 1997) |
| initiation complex | Complex between mRNA, 30S ribosomal subunit and formyl methionyl tRNA that requires GTP and initiation factors to function. (18 Nov 1997) |
| initiation factor | One of several soluble proteins involved in the initiation of protein or RNA synthesis. (05 Mar 2000) |
| initiation factors | The set of catalytic proteins required, in addition to mRNA and ribosomes, for protein synthesis to begin. In bacteria three distinct proteins have been identified: if 1 (8 kD), IF 2 (75 kD) and IF 3 (30 kD). at least 6-8 proteins have been identified in eukaryotes. IFs 1 and 2 enhance the binding of initiator tRNA to the initiation complex. (18 Nov 1997) |
| initiation tRNA | TRNA in prokaryotes containing a formyl-methionyl residue that initiates translation. Synonym: formyl-methionyl-tRNA, starter tRNA. (05 Mar 2000) |
| tumour initiation | <cell biology, oncology> First stage of tumour development. See: tumour progression. (18 Nov 1997) |
| alpha-aminoacyl-peptide hydrolases | <enzyme> Registry number: EC 3.4.11. (12 Dec 1998) |
| anionic neutrophil activating peptide | <cytokine> A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4. Acronym: IL-8 (12 Dec 1998) |
| antibiotics, peptide | Antibiotics whose structure contains one or more peptides, usually cyclic. They are generally effective against gram-positive bacteria and act by inhibiting peptidoglycan synthesis in bacterial cell walls. (12 Dec 1998) |
| atrial natriuretic peptide | <hormone> This cardiac hormone (28 amino acid residues) regulates salt and water balance in body fluids and blood pressure, it has potential as a medication to treat heart and kidney failure and the buildup of excess fluid in tissue. (09 Oct 1997) |